Brain Topography

, Volume 30, Issue 3, pp 312–319 | Cite as

Theta Burst Stimulation of the Precuneus Modulates Resting State Connectivity in the Left Temporal Pole

  • Matteo Mancini
  • Chiara Mastropasqua
  • Sonia Bonnì
  • Viviana Ponzo
  • Mara Cercignani
  • Silvia Conforto
  • Giacomo Koch
  • Marco Bozzali
Original Paper

Abstract

It has been shown that continuous theta burst stimulation (cTBS) over the precuneus acts on specific memory retrieval abilities. In order to study the neural mechanisms beyond these findings, we combined cTBS and resting-state functional magnetic resonance imaging. Our experimental protocol involved stimulation and sham conditions on a group of healthy subjects, and each condition included a baseline and two follow-up acquisitions (5 and 15 min after baseline) after cTBS. We analysed brain functional connectivity by means of graph theoretical measures, with a specific focus on the network modular structure. Our results showed that cTBS of the precuneus selectively affects the left temporal pole, decreasing its functional connectivity in the first follow-up. Moreover, we observed a significant increase in the size of the module of the precuneus in the second follow-up. Such effects were absent in the sham condition. We observed here a modulation of functional connectivity as a result of inhibitory stimulation over the precuneus. Such a modulation first acts indirectly on the temporal area and then extends the connectivity of the precuneus itself by a feed-back mechanism. Our current findings extend our previous behavioural observations and increase our understanding of the mechanisms underlying the stimulation of the precuneus.

Keywords

TMS fMRI cTBS Functional connectivity Graph theory Precuneus 

Abbreviations

TMS

Transcranial magnetic stimulation

fMRI

Functional magnetic resonance imaging

cTBS

Continuous theta burst stimulation

PC

Precuneus

Notes

Acknowledgements

This study was funded by a grant from the Italian Ministry of Health (RF10.047) awarded to Marco Bozzali.

Supplementary material

10548_2017_559_MOESM1_ESM.docx (1.9 mb)
Supplementary material 1 (DOCX 1960 KB)

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of EngineeringUniversity of Rome, “Roma Tre”RomeItaly
  2. 2.Neuroimaging LaboratoryIRCCS Santa Lucia FoundationRomeItaly
  3. 3.Non-Invasive Brain Stimulation UnitIRCCS Santa Lucia FoundationRomeItaly
  4. 4.Brighton & Sussex Medical School, Clinical Imaging Sciences CentreUniversity of SussexBrightonUK
  5. 5.Stroke UnitPoliclinico Tor VergataRomeItaly

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