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Brain Topography

, Volume 30, Issue 5, pp 656–672 | Cite as

Transcranial Direct Current Stimulation Modulates Neuronal Networks in Attention Deficit Hyperactivity Disorder

  • Anna Sotnikova
  • Cornelia Soff
  • Enzo Tagliazucchi
  • Katja Becker
  • Michael SiniatchkinEmail author
Original Paper

Abstract

Anodal transcranial direct current stimulation (tDCS) of the prefrontal cortex has been repeatedly shown to improve working memory (WM). Since patients with attention deficit hyperactivity disorder (ADHD) are characterized by both underactivation of the prefrontal cortex and deficits in WM, the modulation of prefrontal activity with tDCS in ADHD patients may increase their WM performance as well as improve the activation and connectivity of the WM network. In the present study, this hypothesis was tested using a double-blind sham-controlled experimental design. After randomization, sixteen adolescents with ADHD underwent either anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC, 1 mA, 20 min) or sham stimulation with simultaneous fMRI during n-back WM task. Both in one-back and two-back conditions, tDCS led to a greater activation (compared with sham stimulation) of the left DLPFC (under the electrode), left premotor cortex, left supplementary motor cortex, and precuneus. The effects of tDCS were long-lasting and influenced resting state functional connectivity even 20 min after the stimulation, with patterns of strengthened DLPFC connectivity after tDCS outlining the WM network. In summary, anodal tDCS caused increased neuronal activation and connectivity, not only in the brain area under the stimulating electrode (i.e. left DLPFC) but also in other, more remote brain regions. Because of moderate behavioral effects of tDCS, the significance of this technique for ADHD treatment has to be investigated in further studies.

Keywords

ADHD Transcranial direct current stimulation Working memory fMRI 

Notes

Acknowledgements

This work was support by the special grant of the Medical Faculty of the University of Marburg.

Compliance with Ethical Standards

Conflict of interest

The authors reported no biomedical financial interests or potential conflicts of interest.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Anna Sotnikova
    • 1
  • Cornelia Soff
    • 1
  • Enzo Tagliazucchi
    • 2
  • Katja Becker
    • 1
  • Michael Siniatchkin
    • 2
    Email author
  1. 1.Department for Child and Adolescent Psychiatry, Psychosomatics and PsychotherapyPhilipps-UniversityMarburgGermany
  2. 2.Institute of Medical Psychology and Medical SociologyChristian-Albrechts-UniversityKielGermany

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