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Brain Topography

, Volume 30, Issue 5, pp 685–697 | Cite as

High-Resolution fMRI of Auditory Cortical Map Changes in Unilateral Hearing Loss and Tinnitus

  • Naghmeh GhazalehEmail author
  • Wietske van der Zwaag
  • Stephanie Clarke
  • Dimitri Van De Ville
  • Raphael Maire
  • Melissa Saenz
Original Paper

Abstract

Animal models of hearing loss and tinnitus observe pathological neural activity in the tonotopic frequency maps of the primary auditory cortex. Here, we applied ultra high-field fMRI at 7 T to test whether human patients with unilateral hearing loss and tinnitus also show altered functional activity in the primary auditory cortex. The high spatial resolution afforded by 7 T imaging allowed tonotopic mapping of primary auditory cortex on an individual subject basis. Eleven patients with unilateral hearing loss and tinnitus were compared to normal-hearing controls. Patients showed an over-representation and hyperactivity in a region of the cortical map corresponding to low frequencies sounds, irrespective of the hearing loss and tinnitus range, which in most cases affected higher frequencies. This finding of hyperactivity in low frequency map regions, irrespective of hearing loss range, is consistent with some previous studies in animal models and corroborates a previous study of human tinnitus. Thus these findings contribute to accumulating evidence that gross cortical tonotopic map reorganization is not a causal factor of tinnitus.

Keywords

Tinnitus fMRI Primary auditory cortex Neural plasticity 

Notes

Acknowledgements

This work was supported by Swiss National Science Foundation Grant 320030_143989 and by the Centre d’Imagerie BioMédicale (CIBM) of the Université de Lausanne, Université de Genève, Hôpitaux Universitaires de Genève, Lausanne University Hospital, École Polytechnique Fédérale de Lausanne, and the Leenaards and Louis-Jeantet Foundations.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

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© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Institute of BioengineeringÉcole Polytechnique Fédérale de Lausanne (EPFL)LausanneSwitzerland
  2. 2.Department of Radiology and Medical InformaticsUniversity of GenevaGenevaSwitzerland
  3. 3.Spinoza Centre for NeuroimagingRoyal Netherlands Academy for Arts and SciencesAmsterdamNetherlands
  4. 4.Center for Biomedical ImagingUniversity of LausanneLausanneSwitzerland
  5. 5.Service of Neuropsychology and Neurorehabilitation, Department of Clinical Neurosciences Lausanne University HospitalLausanneSwitzerland
  6. 6.Department of Otorhinolaryngology, Head and Neck SurgeryLausanne University HospitalLausanneSwitzerland
  7. 7.Neuroimaging Research Lab (LREN), Department of Clinical NeurosciencesLausanne University HospitalLausanneSwitzerland

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