Brain Topography

, Volume 27, Issue 6, pp 731–746 | Cite as

A Reliability Study on Brain Activation During Active and Passive Arm Movements Supported by an MRI-Compatible Robot

  • Natalia Estévez
  • Ningbo Yu
  • Mike Brügger
  • Michael Villiger
  • Marie-Claude Hepp-Reymond
  • Robert Riener
  • Spyros Kollias
Original Paper

Abstract

In neurorehabilitation, longitudinal assessment of arm movement related brain function in patients with motor disability is challenging due to variability in task performance. MRI-compatible robots monitor and control task performance, yielding more reliable evaluation of brain function over time. The main goals of the present study were first to define the brain network activated while performing active and passive elbow movements with an MRI-compatible arm robot (MaRIA) in healthy subjects, and second to test the reproducibility of this activation over time. For the fMRI analysis two models were compared. In model 1 movement onset and duration were included, whereas in model 2 force and range of motion were added to the analysis. Reliability of brain activation was tested with several statistical approaches applied on individual and group activation maps and on summary statistics. The activated network included mainly the primary motor cortex, primary and secondary somatosensory cortex, superior and inferior parietal cortex, medial and lateral premotor regions, and subcortical structures. Reliability analyses revealed robust activation for active movements with both fMRI models and all the statistical methods used. Imposed passive movements also elicited mainly robust brain activation for individual and group activation maps, and reliability was improved by including additional force and range of motion using model 2. These findings demonstrate that the use of robotic devices, such as MaRIA, can be useful to reliably assess arm movement related brain activation in longitudinal studies and may contribute in studies evaluating therapies and brain plasticity following injury in the nervous system.

Keywords

fMRI Elbow flexion/extension Neurorehabilitation MRI-Compatible robotic devices Reliability Sensorimotor network 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Natalia Estévez
    • 1
    • 2
  • Ningbo Yu
    • 3
    • 4
  • Mike Brügger
    • 3
    • 5
    • 6
  • Michael Villiger
    • 7
    • 8
  • Marie-Claude Hepp-Reymond
    • 8
  • Robert Riener
    • 3
    • 7
  • Spyros Kollias
    • 1
  1. 1.Department of NeuroradiologyUniversity Hospital ZurichZurichSwitzerland
  2. 2.Institute of Social and Preventive MedicineZurichSwitzerland
  3. 3.Sensory-Motor Systems LabInstitute of Robotics and Intelligent Systems, ETH ZurichZurichSwitzerland
  4. 4.Institute of Robotics and Automatic Information SystemNankai UniversityTianjinChina
  5. 5.Institute for Biomedical EngineeringETH Zurich and University of ZurichZurichSwitzerland
  6. 6.Center of Dental MedicineUniversity of ZurichZurichSwitzerland
  7. 7.Spinal Cord Injury CenterUniversity Hospital BalgristZurichSwitzerland
  8. 8.Institute of NeuroinformaticsUniversity of Zurich and ETH ZurichZurichSwitzerland

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