A Functional Neuroimaging Case Study of Meares–Irlen Syndrome/Visual Stress (MISViS)
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The aim of this study is to evaluate the data from a participant in a reading study who had a diagnosis of Meares–Irlen syndrome/visual stress (MISViS). MISViS is characterised by visual distortions and somatic issues, which are remediated using coloured filters. The authors present a case study providing descriptive neurobiological comparisons of MISViS versus a control group. The study involved eleven English language speakers who participated in behavioural and neuroimaging versions of a language experiment with varied proportions of regular and exception words. Behavioural measures included accuracy and response times. Neuroimaging was conducted using a 1.5T Siemens Sonata MRI. The MISViS participant’s data were removed from the overall experiment and analysed as a case study. Impulse response functions (IRFs) and percentage of active voxels were extracted from four regions of interest: BAs 17, 18, 19, and the postcentral gyrus (PG) and two control regions (BA6 and left BA45). The results indicated that significant differences existed between the control group and the MISViS participant for IRF intensity in two regions (BA6 and PG) and percentage of active voxels in four regions (BA17, BA19, PG, and BA6). No significant differences occurred in left BA45 for either variable of interest. No significant differences were found for behavioural measures. In conclusion, our findings offer one of the first neurobiological descriptions of differences in IRF intensity and percentage of active voxels in visual and somatosensory cortex during a language experiment for a participant with MISViS in the absence of migraine compared to controls.
KeywordsMeares–Irlen syndrome Visual stress Functional magnetic resonance imaging (fMRI) Coloured filters Visual perceptual distortions
The authors have no commercial interest in tinted lenses or related therapies for learning disabilities. The authors would like to thank all participants for their involvement in this study and two anonymous reviewers for their insight and guidance.
- Cox RW (1996) AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29:162–173. [AFNI 3-D anatomical brain http://afni.nimh.nih.gov/old/afni/astrip+orig.HEAD (and BRIK)]
- Hubel DH (1995) Eye, brain, and vision. Scientific American Library, New YorkGoogle Scholar
- Irlen H (1983) Successful Treatment of Learning Disabilities. In: Paper presented at the annual convention of the American Psychological Association, AnaheimGoogle Scholar
- Irlen H (1998) Irlen method & reading problems. Retrieved 15 June 2011, from Irlen Institute Web site http://irlen.com/index.php?id=145
- Irlen H (1999) Irlen reading perceptual scale, revised. Perceptual Development Corporation, Long BeachGoogle Scholar
- Irlen H (2010) The Irlen revolution: how a simple method can change the lives of children and adults with LD, AD/HD, TBI, dyslexia, autism, headaches, medical conditions, and much more. Square One Publishers, Garden City ParkGoogle Scholar
- Meares O (1980) Figure/ground brightness contrast, and reading disabilities. Visible Lang 14:13–29Google Scholar
- Simmers AJ, Bex PJ, Smith FKH, Wilkins A (2001) Spatiotemporal visual function in tinted lens wearers. Investig Ophthalmol Vis Sci 42(3):879–884Google Scholar
- Wilkins A (1993) Reading and visual discomfort. In: Willows EM, Kruk RS, Corcos E (eds) Visual processes in reading and reading disabilities. Lawrence Erlbaum Associates, Hillsdale, pp 435–456Google Scholar
- Wilkins A (2003) Reading through colour: how coloured filters can reduce reading difficulty, eye strain and headaches. Wiley, ChichesterGoogle Scholar
- Wilkins AJ, Evans BJW (2001, 2010) Pattern glare test instructions. I.O.O. Sales Ltd, LondonGoogle Scholar