Neuromagnetic Changes of Brain Rhythm Evoked by Intravenous Olfactory Stimulation in Humans
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To identify the changes in the respective frequency band and brain areas related to olfactory perception, we measured magnetoencephalographic (MEG) signals before and after instilling intravenously thiamine propyl disulfide (TPD) and thiamine tetrahydrofurfuryl disulfide monohydrochloride (TTFD), which evoked a strong and weak sensation of odor, respectively. For the frequency analysis of MEG, a beamformer program, synthetic aperture magnetometry (SAM), was employed and event-related desynchronization (ERD) or synchronization (ERS) was statistically determined. Both strong and weak odors induced ERD in (1) beta band (13–30 Hz) in the right precentral gyrus, and the superior and middle frontal gyri in both hemispheres, (2) low gamma band (30–60 Hz) in the left superior frontal gyrus and superior parietal lobule, and the middle frontal gyrus in both hemispheres, and (3) high gamma band 2 (100–200 Hz) in the right inferior frontal gyrus. TPD induced ERD in the left temporal, parietal and occipital lobes, while TTFD induced ERD in the right temporal, parietal and occipital lobes. The results indicate that physiological functions in several regions in the frontal lobe may change and the strength of the odor may play a different role in each hemisphere during olfactory perception in humans.
Key words:Magnetoencephalography Synchronization Desynchronization Odor Gamma band SAM MEG
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- Adrian, E.D. Olfactory reactions in the brain of the hedgehog. J. Physiol., 1942, 100: 459–473.Google Scholar
- Bresseler, S.L. and Freeman, W.J. Frequency analysis of olfactory system EEG in cat, rabbit, and rat. Electroencephalogr. Clin. Neurophysiol., 1980, 50: 19–24.Google Scholar
- Hirata, M., Kato, A., Taniguchi, M., Ninomiya, H., Cheyne, D., Robinson, S.E., Maruno, M., Kumura, E., Ishii, R., Hirabuki, N., Nakamura, H. and Yoshimine, T. Frequency-dependent spatial distribution of human somatosensory evoked neuromagnetic fields. Neurosci. Lett., 2002, 318: 73–76.CrossRefPubMedGoogle Scholar
- Hirata, M., Kato, A., Taniguchi, M., Saitoh, Y., Ninomiya, H., Ihara, A., Kishima, H., Oshino, S., Baba, T., Yorihuji, S. and Yoshimine, T. Determination of language dominance with synthetic aperture magnetometry: comparison with the Wada test. Neuroimage, 2004, 23: 46–53.CrossRefPubMedGoogle Scholar
- Klemm, W.R., Lutes, S.D., Hendrix, D.V. and Warrenberg, S. Topographical EEG maps of human responses to odor. Chem. Senses, 1992, 17: 347–361.Google Scholar
- Koizuka, I., Yano, H., Nagahara, M., Mochizuki, R., Seo, R., Shimada, K., Kubo, T. and Nogawa, T. Functional imaging of the human olfactory cortex by magnetic resornance imaging. ORL J. Otorhinolaryngol. Relat. Spec., 1994, 53: 273–275.Google Scholar
- Lorig, T.S., Huffman, E., DeMartino, A. and DeMarco, J. The effects of low concentration odors on EEG activity and behaviour. J. Psychophysiol., 1991, 9: 178–179.Google Scholar
- Robinson, S.E. and Vrba, J. Functional neuroimaging by synthetic aperture magnetometry (SAM). In: T. Yoshimoto, M. Kotani, S. Kuriki, H. Karibe, and N. Nakasato (Eds.), Recent Advances in Biomagnetism. Tohoku University Press, Sendai, Japan, 1999: 302–305.Google Scholar
- Taniguchi, M., Kato, A., Fujita, N., Hirata, M., Tanaka, H., Kihara, T., Ninomiya, H., Hirabuki, N., Nakamura, H., Robinson, S.E., Cheyne, D. and Yoshimine, T. Movement-related desynchronization of the cerebral cortex studied with spatially filtered magnetoencephalography. Neuroimage, 2000, 12: 298–306.CrossRefPubMedGoogle Scholar
- Tonoike, M., Yamaguchi, M., Kaetsu, I., Kida, H., Seo, R. and Koizuka, I. Ipsilateral dominance of human olfactory activated centers estimated from event-related magnetic fields measured by 122-channel whole-head neuromagnetometer using odorant stimuli synchronized with respirations. Ann. N.Y. Acad. Sci., 1998, 855: 579–590.CrossRefPubMedGoogle Scholar
- Yano. Studies on the nutritional value of allium plants: changes of thiamine contents in the blood after oral or parenteral administration of allithiamine. Vitamin, 1958, 15: 617–621. (in Japanese).Google Scholar