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Avascular necrosis after long-term glucocorticoid treatment in MELAS: a cautionary note

  • Images in Metabolic Medicine
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Journal of Inherited Metabolic Disease

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References

  • El-Hattab AW, Adesina AM, Jones J, Scaglia F (2015) MELAS syndrome: clinical manifestations, pathogenesis, and treatment options. Mol Genet Metab 116:4–12

    Article  CAS  PubMed  Google Scholar 

  • Finsterer J (2009) Management of mitochondrial stroke-like episodes. Eur J Neurol 16:1178–1184

    Article  CAS  PubMed  Google Scholar 

  • Ficat RP (1985) Idiopathic bone necrosis of the femoral head: early diagnosis and treatment. J Bone Joint Surg Br 67:3–9

    Article  CAS  PubMed  Google Scholar 

  • Fryer RH, Bain J, De Vivo D (2016) Mitochondrial Encephalomyopathy lactic acidosis and stroke-like episodes: a case report and critical reappraisal of treatment options. Pediatr Neurol 56:59–61

    Article  PubMed  Google Scholar 

  • Jing D, Wang Y, Hunter R, Wei Y, Blumenthal R, Falke C et al (2009) Dynamic regulation of mitochondrial function by glucocorticoids. PNAS 106(9):3543–3548

    Article  Google Scholar 

  • Parikh S, Goldstein A, Karaa A, Koenig MK, Anselm I, Brunel-Guitton C et al (2017) Patient care standards for primary mitochondrial disease: a consensus statement from the mitochondrial medicine society. Genet Med. https://doi.org/10.1038/gim.2017.107

  • Parikh S, Goldstein A, Koenig MK, Scaglia F, Enns GM, Saneto R et al (2015) Diagnosis and management of mitochondrial disease: a consensus statement from the mitochondrial medicine society. Genet Med 17(9):689–701

    Article  CAS  PubMed  Google Scholar 

  • Rossi FH, Okun M, Yachnis A, Quisling R, Triggs WJ (2002) Corticosteroid treatment of mitochondrial encephalomyopathies. Neurologist 8:313–315

    Article  PubMed  Google Scholar 

  • Walcott BP, Edlow BL, Xia Z, Kahle KT, Nahed BV, Schmahmann JD (2012) Steroid responsive A3243G mutation MELAS: clinical and radiographic evidence for regional hyperperfusion leading to neuronal loss. Neurologist 18(3):159–170

    Article  PubMed  Google Scholar 

  • Weinstein RS (2012) Glucocorticoid-induced osteonecrosis. Endocrine 41(2):183–190

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, Republic of Korea

    Han Som Choi, Jae Hyun Lee, Sun Ho Lee & Young-Mock Lee

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  1. Han Som Choi
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  2. Jae Hyun Lee
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  3. Sun Ho Lee
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  4. Young-Mock Lee
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Correspondence to Young-Mock Lee.

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All procedures performed in studies involving human participant were in accordance with the ethical standards of the institutional and national research committee.

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Informed consent was obtained from the patient included in the study.

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Communicated by: Eva Morava

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Choi, H.S., Lee, J.H., Lee, S.H. et al. Avascular necrosis after long-term glucocorticoid treatment in MELAS: a cautionary note. J Inherit Metab Dis 41, 277–278 (2018). https://doi.org/10.1007/s10545-017-0110-y

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  • DOI: https://doi.org/10.1007/s10545-017-0110-y

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