Journal of Inherited Metabolic Disease

, Volume 32, Supplement 1, pp 111–113

Four successful pregnancies in a patient with mucopolysaccharidosis type I treated by allogeneic bone marrow transplantation

  • G. Remérand
  • E. Merlin
  • R. Froissart
  • F. Brugnon
  • J. Kanold
  • L. Janny
  • F. Deméocq
Short Report

Summary

To date, little is known about the fertility of women suffering from mucopolysaccharidosis type I (MPS I). We report on a female patient with MPS I treated by allogeneic bone marrow transplantation (BMT) at the age of 4 years (after a conditioning regimen containing busulfan 16 mg/kg and cyclophosphamide 100 mg/kg) who had four successful pregnancies without any reproductive assistance. Clinical and biological examinations of the children were normal. On the basis of this case, we discuss the fertility counselling of female MPS I patients at the time of BMT.

Abbreviations

BMT

bone marrow transplantation

GAG

glycosaminoglycan

GVHD

graft-versus-host disease

MPS I

mucopolysaccharidosis type I

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • G. Remérand
    • 1
  • E. Merlin
    • 1
    • 2
    • 3
    • 6
  • R. Froissart
    • 4
  • F. Brugnon
    • 3
    • 5
  • J. Kanold
    • 1
    • 2
    • 3
  • L. Janny
    • 3
    • 5
  • F. Deméocq
    • 1
    • 2
    • 3
  1. 1.CHU Clermont-FerrandCentre Régional de Cancérologie et Thérapie Cellulaire PédiatriqueClermont-FerrandFrance
  2. 2.Inserm, CIC501Clermont-FerrandFrance
  3. 3.Clermont UniversitéClermont-FerrandFrance
  4. 4.Hospices Civils de Lyon, Laboratoire des Maladies Héréditaires du MétabolismeCentre de Biologie et de Pathologie EstBron cedexFrance
  5. 5.CHU Clermont-FerrandBiologie du Développement et de la Reproduction, CECOSClermont Ferrand cedex 1France
  6. 6.Centre Régional de Cancérologie et Thérapie Cellulaire PédiatriqueClermont-FerrandFrance

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