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Journal of Inherited Metabolic Disease

, Volume 30, Issue 3, pp 388–399 | Cite as

Statin therapy depresses total body fat oxidation in the absence of genetic limitations to fat oxidation

  • N. M. Fisher
  • K. Meksawan
  • A. Limprasertkul
  • P. J. Isackson
  • D. R. Pendergast
  • G. D. Vladutiu
Original Article

Summary

Cholesterol lowering drugs are associated with myopathic side effects in 7% of those on therapy, which is reversible in most, but not all patients. This study tested the hypothesis that total body fat oxidation (TBFO) is reduced by statins in patients with genetic deficiencies in FO, determined by white blood cells (FOwbc) and by molecular analysis of common deficiencies, and would cause intolerance in some patients. Six patients on statin therapy without myopathic side effects (tolerant) and 7 patients who had previously developed statin-induced myopathic symptoms (intolerant) (age=58 ± 8.25 yrs, ht.=169±11 cm, and wt. = 75.4 ±14.2 kg) were tested for TBFO (Respiratory Exchange Ratio, RER) pre- and during exercise. FOwbc was not significantly different between tolerant and intolerant (0.261 ±0.078 vs. 0.296 ±0.042 nmol/h per 109 wbc), or normals (0.27 ±0.09 nmol/h per 109 wbc) and no common molecular abnormalities were found. Pre-exercise RER (0.73 ±0.05 vs. 0.84 ±0.05) was significantly lower in the intolerant group and the Vo 2 at RER=1.0 (1.27 ±0.32 vs. 1.87±0.60 L/min) greater than the tolerant. Post-exercise lactates were not different between groups. Although dietary fat intake was not different, blood lipoprotein levels, particularly triglycerides were 35% lower in tolerant than previously intolerant. TBFO and blood lipoproteins were reduced in tolerant patients in spite of the absence of genetic limitations, but not in the intolerant group as hypothesized. Although not conclusive, these data suggest the need for a prospective study of the effects of statins on fat oxidation.

Keywords

Statin Statin Therapy Respiratory Exchange Ratio AMPD Tolerant Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CHO

carbohydrates

CK

creatine kinase

FFA

free fatty acids

FOwbc

fat oxidation by white blood cells

HDL-C

high-density lipoprotein cholesterol

HMG CoA

hydroxymethylglutaryl-coenzyme A

HR

heart rate

LDL-C

low-density lipoprotein cholesterol

RER

respiratory exchange ratio

TBFO

total body fat oxidation

TC

total cholesterol

TG

triglycerides

VLDL-C

very low-density lipoprotein cholesterol

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Copyright information

© SSIEM and Springer 2007

Authors and Affiliations

  • N. M. Fisher
    • 1
  • K. Meksawan
    • 7
  • A. Limprasertkul
    • 2
  • P. J. Isackson
    • 3
  • D. R. Pendergast
    • 4
  • G. D. Vladutiu
    • 3
    • 5
    • 6
  1. 1.Department of Rehabilitation Science, School of Public Health and Health ProfessionsUniversity at BuffaloBuffaloUSA
  2. 2.Department of Exercise and Nutrition SciencesUniversity at BuffaloBuffaloUSA
  3. 3.Department of PediatricsUniversity at BuffaloBuffaloUSA
  4. 4.Department of Physiology and BiophysicsUniversity at BuffaloBuffaloUSA
  5. 5.Department of PathologyUniversity at BuffaloBuffaloUSA
  6. 6.Department of NeurologyUniversity at BuffaloBuffaloUSA
  7. 7.Faculty of Pharmaceutical Sciences at Chulalongkorn UniversityBangkokThailand

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