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Journal of Inherited Metabolic Disease

, Volume 29, Issue 5, pp 688–689 | Cite as

Successful treatment of pyridoxine-unresponsive homocystinuria with betaine in pregnancy

  • Germaine Pierre
  • Paul Gissen
  • Anupam Chakrapani
  • Anita McDonald
  • MaryAnne Preece
  • Joy Wright
Letter to the Editor

References

  1. Levy HL, Vargas JE, Waisbren SE, et al (2002) Reproductive fitness in maternal homocystinuria due to cystathione β-synthase deficiency. J Inherit Metab Dis 25: 299–314.PubMedCrossRefGoogle Scholar
  2. Mathews A, Johnson TN, Chakrapani A, et al (2002) An indirect response model of homocyteine suppression by betaine: optimising the dosage regimen of betaine in homocystinuria. J Clin Pharmacol 54: 140–146.CrossRefGoogle Scholar
  3. Mudd SH, Levy HL, Kraus JD (2001) Disorders of transsulfuration. In: Scriver CR, Sly WS, Valle D, eds; Childs B, Kinzler KW, Vogelstein B, assoc. eds. The Metabolic and Molecular Bases of Inherited Disease, 8th edn. New York: McGraw-Hill, 2007–2056.Google Scholar
  4. Vilaseca MA, Cuartero ML, Martinez de Salinas M, et al (2004) Two successful pregnancies in pyridoxine-nonresponsive homocystinuria. J Inherit Metab Dis 27: 775–777.PubMedCrossRefGoogle Scholar
  5. Yap S, Barry-Kinsella C, Naughten ER (2001) Maternal pyridoxine non-responsive homocystinuria: the role of dietary treatment and anticoagulation. Br J Obstet Gynaecol 108: 425–428.CrossRefGoogle Scholar

Copyright information

© SSIEM and Springer 2006

Authors and Affiliations

  • Germaine Pierre
    • 1
  • Paul Gissen
    • 1
  • Anupam Chakrapani
    • 1
  • Anita McDonald
    • 1
  • MaryAnne Preece
    • 1
  • Joy Wright
    • 1
  1. 1.Birmingham Children’s HospitalBirminghamUK

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