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An overview on the exponential growth of non-invasive diagnosis of diabetes mellitus from exhaled breath by nanostructured metal oxide Chemi-resistive gas sensors and μ-preconcentrator

  • Ramji Kalidoss
  • Snekhalatha UmapathyEmail author
Article
  • 21 Downloads

Abstract

The characterization of acetone in exhaled breath reflects the internal metabolism of glucose in bloodstream and airways. This phenomenon provides a great potential for non-invasive diagnosis of diabetes mellitus and has inspired medical sodalities as an alternative diagnostic tool. This review discusses about the origination of acetone in breath, its correlation with blood glucose level along with the ways to collect breath sample. Furthermore, we also discuss the detection of acetone by chemical sensors with emphasis on the use of pre-concentrators on a single lab-on-chip for the diagnosis of diabetes mellitus. Finally, this review outlines the future directions for the detection of acetone from exhaled breath. The first part of the review introduces the biochemistry and prevalence of diabetes in India along with the existing techniques to estimate the concentration of acetone. The second part focuses on the semiconducting metal oxide and polymer gas sensors which discusses about tailoring the dynamic sensitivity range and selectivity towards acetone in breath. The third part elaborates on the ways to pre-concentrate the target biomarkers along with future perspectives for non-invasive diabetes diagnosis. Finally we also provide the perspectives on future challenges to make it to clinical practice.

Graphical abstract

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Keywords

Acetone Diabetes mellitus Micro-cantilever Pre-concentrator 

Notes

Acknowledgments

The authors are thankful to the Department of Biomedical Engineering, SRM Institute of Science & Technology for encouraging the research and providing necessary financial assistance.

References

  1. H. Ahn, Y. Wang, S.H. Jee, M. Park, Y.S. Yoon, D.J. Kim, Chem. Phys. Lett. 511, 331 (2011)CrossRefGoogle Scholar
  2. M. Alexiadou, M. Kandyla, G. Mousdis, M. Kompitsas, Appl. Phys. A 123, 262 (2017)CrossRefGoogle Scholar
  3. J.C. Anderson, Obesity 23, 2327 (2015)CrossRefGoogle Scholar
  4. J.C. Anderson, W.J.E. Lamm, M.P. Hlastala, J. Appl. Physiol. 100, 880 (2006)CrossRefGoogle Scholar
  5. Biomarkers Definitions Working Group Clinical Pharmacology & Therapeutics 69 89–95 (2001)Google Scholar
  6. T.A. Betts, C.A. Tipple, M.J. Sepaniak, P.G. Datskos, Anal. Chim. Acta 422, 89 (2000)CrossRefGoogle Scholar
  7. T.P. Burg, M. Godin, S.M. Knudsen, W. Shen, G. Carlson, J.S. Foster, K. Babcock, S.R. Manalis, Nature 446, 1066 (2007)CrossRefGoogle Scholar
  8. S. Chakraborty, D. Banerjee, I. Ray, A. Sen, Curr. Sci. 94, 237 (2008)Google Scholar
  9. T.Y. Chen, M.J. Li, J.L. Wang, J. Chromatogr. A 976, 39 (2002)CrossRefGoogle Scholar
  10. X. Cheng, Y. Xu, S. Gao, H. Zhao, L. Huo, Sensors Actuators B 155, 716 (2011)CrossRefGoogle Scholar
  11. S.M. Cho, Y.J. Kim, G.S. Heo, S.M. Shin, Sensors Actuators B Chem. 117, 50 (2006)CrossRefGoogle Scholar
  12. S.J. Choi, B.H. Jang, S.J. Lee, B.K. Min, A. Rothschild, I.D. Kim, Appl. Mater. Interfaces 6, 2588 (2014)CrossRefGoogle Scholar
  13. X. Chu, P. Dai, S. Liang, A. Bhattacharya, Y. Dong, M. Epifani, Physica E Low Dimens Syst Nanostruct 106, 326 (2019)CrossRefGoogle Scholar
  14. P.K. Chuang, L.C. Wang, C.T. Kuo, Thin Solid Films 529, 205 (2013)CrossRefGoogle Scholar
  15. A. Daneshkhah, S. Shrestha, M. Agarwal, K. Varahramyan, Sensors Actuators B 221, 635 (2015)CrossRefGoogle Scholar
  16. S. Das, S. Pal, M. Mitra, J. Med. Biol. Eng. 36(605) (2016)CrossRefGoogle Scholar
  17. C. Deng, J. Zhang, X. Yu, W. Zhang, X. Zhang, J. Chromatogr. B 810, 269 (2004)CrossRefGoogle Scholar
  18. M. Ding, D.C. Sorescu, A. Star, J. Am. Chem. Soc. 135, 9015 (2013)CrossRefGoogle Scholar
  19. J.S. Do, S.H. Wang, Sensors Actuators B 185, 39 (2013)CrossRefGoogle Scholar
  20. Y. Dong, W. Gao, Q. Zhou, Y. Zheng, Z. You, Anal. Chim. Acta 671, 85 (2010)CrossRefGoogle Scholar
  21. Executive Summary of India Council of Medical Research Youth Diabetes Registry Phase – 1 Report http://icmr.nic.in/final/diabetes/Executive%20summary%20YDR%2025082014.pdf
  22. L. Fadel, F. Lochon, I. Dufour, O. Francais, J. Micromech. Microeng. 14, 23 (2004)CrossRefGoogle Scholar
  23. N. Fens, M.P. Van der Schee, P. Brinkman, P.J. Sterk, Clin. Exp. Allergy 43, 705 (2013)CrossRefGoogle Scholar
  24. I. Gracia, P. Ivanov, F. Blanco, N. Sabate, X. Vilanova, X. Correig, L. Fonseca, E. Figueras, J. Santander, C. Cane, Sensors Actuators B 132, 149 (2008)CrossRefGoogle Scholar
  25. A. Hasani, H.S. Dehsari, J.N. Gavgani, E.K. Shalamzari, A. Salehi, F.A. Taromi, M. Mahyari, Microchim. Acta 182, 1551 (2015)CrossRefGoogle Scholar
  26. J. Hu, Y. Wang, W. Wang, Y. Xue, P. Li, K. Lian, L. Chen, W. Zhang, S. Zhuiykov, J. Mater. Sci. 52, 11554 (2017)CrossRefGoogle Scholar
  27. Q.Q. Jia, H.M. Ji, P. Gao, X. Bai, Z.G. Jin, J. Mater. Sci. Mater. Electron. 26, 5792 (2015)CrossRefGoogle Scholar
  28. R. Kalidoss, S. Umapathy, R. Anandan, V. Ganesh, Y. Sivalingam, Anal. Chem. 91, 5116 (2019)CrossRefGoogle Scholar
  29. K.W. Kao, M.C. Hsu, Y.H. Chang, S. Gwo, J.A. Yeh, Sensors 12, 7157 (2012)CrossRefGoogle Scholar
  30. J. Kaur, K. Anand, K. Anand, R. C. Singh, J. Mater. Sci. 53 12894 (2018)Google Scholar
  31. N. Kilinc, O. Cakmak, A. Kosemen, E. Ermek, S. Ozturk, Y. Yerli, Z.Z. Ozturk, H. Urey, Sensors Actuators B 202, 357 (2014)CrossRefGoogle Scholar
  32. J. King, P. Mochalski, A. Kupferthaler, K. Unterkofler, H. Koc, W. Filipiak, S. Teschl, H. Hinterhuber, A. Amann, Physiol. Meas. 31, 1169 (2010)CrossRefGoogle Scholar
  33. S. Kischkel, W. Miekisch, A. Sawacki, E.M. Straker, P. Trefz, A. Amann, J.K. Schubert, Clin. Chim. Acta 411, 1637 (2010)CrossRefGoogle Scholar
  34. J. Lee, M. Jung, S. Barthwal, S. Lee, S.H. Lim, Biochip J. 9, 44 (2014)CrossRefGoogle Scholar
  35. J.H. Leopold, R.T.M.V. Hooijdonk, P.J. Sterk, A.A. Hanna, M.J. Schultz, L.D. Bos, BMC Anesthesiol. 14, 46 (2014)CrossRefGoogle Scholar
  36. D. Lian, B. Shi, R. Dai, X. Jia, X. Wu, J. Nanopart. Res. 19, 401 (2017)CrossRefGoogle Scholar
  37. Y. Lin, H. Ji, Z. Shen, Q. Jia, D. Wang, J. Mater. Sci. Mater. Electron. 27, 2086 (2016)CrossRefGoogle Scholar
  38. Z. Liu, T. Yang, Y. Dong, X. Wang, Sensors 18, 3113 (2018)CrossRefGoogle Scholar
  39. C.J. Lu, E.T. Zellers, Anal. Chem. 73, 3449 (2001)CrossRefGoogle Scholar
  40. C.J. Lu, E.T. Zellers, Analyst 127, 1061 (2002)CrossRefGoogle Scholar
  41. D. Maity, K. Rajavel, R.T.R. Kumar, Sensors Actuators B 261, 297 (2018)CrossRefGoogle Scholar
  42. S. K. Mohapatra, S. K. Mahapatra, S. K. Tripathy, L. Kanoje In Proceedings of the First International Conference on Intelligent Computing and Communication. Advances in Intelligent Systems and Computing ed. by J. Mandal, S. Satapathy, M. Sanyal, V. Bhateja (Springer, Singapore, 2017), p. 17Google Scholar
  43. M.E. O’Hara, T.H.C. Brock, S. Green, C.A. Mayhew, J. Breath Res. 3, 027005 (2009)CrossRefGoogle Scholar
  44. C. Peng, J. Guo, W. Yang, C. Shi, M. Liu, Y. Zheng, J. Xu, P. Chen, T. Huang, Y. Yang, J. Alloys Compd. 654, 371 (2016)CrossRefGoogle Scholar
  45. L. Peng, T.F. Xie, M. Yang, P. Wang, D. Xu, S. Pang, D.J. Wang, Sensors Actuators B 131, 660 (2008)CrossRefGoogle Scholar
  46. T. Pisarkiewicz, W. Maziarz, A. Rydosz, J. Mueller, M. Mach, Procedia Eng. 5, 1244 (2010)CrossRefGoogle Scholar
  47. A. Rydosz, J. Microelectr. Electr. Compon. Mater. 44, 126 (2014)Google Scholar
  48. A. Rydosz, W. Maziarz, T. Pisarkiewicz, K. Domański, P. Grabiec, Microelectron. Reliab. 52, 2640 (2012)CrossRefGoogle Scholar
  49. A. Rydosz, D. Michon, K. Domanski, W. Maziarz, T. Pisarkiewicz, Adv. Electr. Comput. En. 14, 59 (2016)Google Scholar
  50. S. Sachdeva, R. Agarwal, A. Agarwal, Microsyst. Technol. 1 (2018a)Google Scholar
  51. S. Sachdeva, R. Agarwal, A. Agarwal, Bull. Mater. Sci. 41, 105 (2018b)CrossRefGoogle Scholar
  52. S. Salehi, E. Nikan, A.A. Khodadadi, Y. Mortazavi, Sensors Actuators B 205, 261 (2014)CrossRefGoogle Scholar
  53. J.H. Seo, S.K. Kim, E.T. Zellers, K. Kurabayashi, Lab Chip 12, 717 (2012)CrossRefGoogle Scholar
  54. N. Shiraishi, T. Ikehara, D.V. Dao, S. Sugiyama, Y. Ando, Sensors Actuators A 202, 233 (2013)CrossRefGoogle Scholar
  55. P. Si, J. Mortensen, A. Komolov, J. Denborg, P.J. Moller, Anal. Chim. Acta 597, 223 (2007)CrossRefGoogle Scholar
  56. D. Smith, P. Spanel, A.A. Fryer, F. Hanna, G.A.A. Ferns, J. Breath Res. 5, 022001 (2011)CrossRefGoogle Scholar
  57. C. Steffens, F.L. Leite, A. Manzoli, R.D. Sandoval, O. Fatibello, P.S.P. Herrmann, J. Nanosci. Nanotechnol. 14, 6718 (2014)CrossRefGoogle Scholar
  58. L. Sun, Z. Yao, A.A. Haidry, Z. Li, Q. Fatima, L. Xie, J. Mater. Sci. Mater. Electron. 29, 14546 (2018)CrossRefGoogle Scholar
  59. M. Sun, Z. Chen, Z. Gong, X. Zhao, C. Jiang, Y. Yuan, Z. Wang, Y. Li, C. Wang, Anal. Bioanal. Chem. 407, 1641 (2015)CrossRefGoogle Scholar
  60. C. Turner, C. Walton, S. Hoashi, M. Evans, J. Breath Res. 3, 046004 (2009)CrossRefGoogle Scholar
  61. I. Ueta, Y. Saito, M. Hosoe, M. Okamoto, H. Ohkita, S. Shirai, H. Tamura, K. Jinno, J. Chromatogr. B 877, 2551 (2009)CrossRefGoogle Scholar
  62. A. Vomiero, S. Bianchi, E. Comini, G. Faglia, M. Ferroni, G. Sberveglieri, Cryst. Growth Des. 7, 2500 (2007)CrossRefGoogle Scholar
  63. C. Wang, A.B. Surampudi, Meas. Sci. Technol. 19, 105604 (2008)CrossRefGoogle Scholar
  64. C. Wang, A. Mbi, M. Sheperd, IEEE Sensors J. 10, 54 (2010)CrossRefGoogle Scholar
  65. L. Wang, A. Teleki, S. Pratsinis, P. Gouma, Chem. Mater. 20, 4794 (2008)CrossRefGoogle Scholar
  66. Z. Wang, C. Wang, J. Breath Res. 7, 037109 (2013)CrossRefGoogle Scholar
  67. S. Wei, J. Zhao, W. Du, Ceram. Int. 41, 769 (2015)CrossRefGoogle Scholar
  68. M.Y. Wong, W.R. Cheng, M.H. Liu, W.C. Tian, C.J. Lu, Talanta 101, 307 (2012)CrossRefGoogle Scholar
  69. T. Xiao, X.Y. Wang, Z.H. Zhao, L. Li, L. Zhang, H.C. Yao, J.S. Wang, Z.J. Li, Sensors Actuators B 199, 210 (2014)CrossRefGoogle Scholar
  70. R. Xing, L. Xu, J. Song, C. Zhou, Q. Li, D. Liu, H.W. Song, Sci. Rep. 5, 10717 (2015)CrossRefGoogle Scholar
  71. D. Zhang, A. Liu, H. Chang, B. Xia, RSC Adv. 5, 3016 (2015)CrossRefGoogle Scholar
  72. M.G. Zhou, Y. Liu, W.W. Li, X. Yuan, X.F. Zhan, J. Li, Y.X. Duan, Y. Liu, Z.H. Gao, Y. Cheng, S.Q. Cheng, H. Li, Y. Liang, Chin. Sci. Bull. 59, 1992 (2014)CrossRefGoogle Scholar
  73. L. Zhu, W. Zeng, Sensors Actuators A (2017)Google Scholar
  74. Y.A. Zolotov, J. Anal. Chem. 60, 497 (2005)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringSRM Institute of Science and TechnologyKattankulathurIndia

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