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Biomedical Microdevices

, 21:53 | Cite as

Highly aligned and geometrically structured poly(glycerol sebacate)-polyethylene oxide composite fiber matrices towards bioscaffolding applications

  • Daniel O’Brien
  • Andrew Hankins
  • Nady Golestaneh
  • Makarand ParanjapeEmail author
Article
  • 424 Downloads

Abstract

The biocompatible and biodegradable polymer poly(glycerol sebacate), or PGS, is a rubber-like material that finds use in several biomedical applications. PGS is often cast into a mold to form desired structures; alternatively, blending PGS with other reinforcing polymers produces viscous solutions that can be spun into non-woven fibrous scaffolds. For tissue scaffolding applications, ordered fibrous matrices are advantageous and have been shown to promote cell orientation and proliferation by contact guidance, providing topographical cues for the seeded cells. The development of techniques for easily producing aligned fibrous matrices is therefore a priority. PGS nanofibers have been fabricated successfully using electrospinning techniques. For producing PGS microfibers, we introduce the electro-less STRAND (Substrate Translation and Rotation for Aligned Nanofiber Deposition) process as an alternative to electrospinning. STRAND provides superior control of fiber properties including diameter, alignment, spacing, and therefore deposition density by mechanically drawing polymer fibers from solution. The goal in using this method is the simple production of aligned PGS fiber matrices for retinal tissue scaffolding.

Keywords

Biocompatible polymer Biomedical Tissue engineering Aligned scaffold Poly(glycerol sebacate) 

Notes

Acknowledgements

The authors would like to thank Leon Der and Jasper Nijdam (Georgetown University) for their input and technical assistance in the project. Daniel O’Brien would like to thank the NSF-REU program for funding through Grant DMR-1358978.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of PhysicsGeorgetown UniversityWashingtonUSA
  2. 2.Department of Opthalmology and NeurologyGeorgetown University Medical CenterWashingtonUSA

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