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Self-powered infusion microfluidic pump for ex vivo drug delivery

  • Francesco Dal Dosso
  • Tadej Kokalj
  • Jaroslav Belotserkovsky
  • Dragana Spasic
  • Jeroen Lammertyn
Article
  • 315 Downloads

Abstract

In this work, we present a new iSIMPLE concept (infusion Self-powered Imbibing Microfluidic Pump by Liquid Encapsulation), which requires no external power for activation nor liquid manipulation, it is easy to use while its fabrication method is extremely simple, inexpensive and suited for mass replication. The pump consists of a working liquid, which is - after finger activation - absorbed in a porous material (e.g. filter paper). The air expelled from the porous material increases the pressure in the downstream outlet channel and propels the outlet liquid (i.e. the sample) through the channel or ejects it. Here we investigated the influence of different filter papers on the iSIMPLE flow rates, achieving a wide range from 30 down to 0.07 μL/min. We also demonstrated the versatility of the iSIMPLE in terms of the liquid volume that can be manipulated (from 0.5 μL up to 150 μL) and the working pressure reaching 64 kPa, unprecedented high for a self-powered microfluidics pump. In addition, using a 34 G microneedle mounted on the iSIMPLE, we successfully injected liquids with different viscosities (from 0.93 up to 55.88 cP) both into an agarose matrix and a skin-like biological ex vivo substrate (i.e. chicken breast tissue). This work validated the compatibility of the iSIMPLE with drug delivery in a controlled way into a skin-like matrix, envisioning a whole new scenario for intradermal injections using self-contained skin patch. In addition, due to the extreme flexibility of the design and manufacturing, the iSIMPLE concept offers enormous opportunities for completely autonomous, portable and cost effective LOC devices.

Keywords

Passive pump Disposable pump Infusion pump Self-powered microfluidics Lab-on-a-chip Drug delivery 

Notes

Acknowledgments

The research leading to these results has received funding from the Research Foundation - Flanders (FWO G086114 N), and the KU Leuven (OT 13/058, C3 project C32/17/007, C2 project C24/16/022).

Compliance with ethical standards

Competing interests

The authors declare no conflict of interest.

Supplementary material

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Francesco Dal Dosso
    • 1
  • Tadej Kokalj
    • 1
  • Jaroslav Belotserkovsky
    • 1
  • Dragana Spasic
    • 1
  • Jeroen Lammertyn
    • 1
  1. 1.Department of Biosystems, MeBioS-Biosensors GroupKU LeuvenLeuvenBelgium

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