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Biomedical Microdevices

, 17:76 | Cite as

Effect of TiO2 nanotubes arrays on osseointegration of orthodontic miniscrew

  • Insan Jang
  • Seong-Cheol Shim
  • Dong-Soon Choi
  • Bong-Kuen Cha
  • Jae-Kwan Lee
  • Byung-Hak Choe
  • Won-Youl ChoiEmail author
Article

Abstract

To increase the stability of orthodontic miniscrews, TiO2 nanotube arrays were fabricated on the surface of Ti miniscrews and the effect of those arrays on the osseointegration of miniscrews was evaluated. Highly ordered TiO2 nanotube arrays were grown on the surface of orthodontic miniscrews. Ethylene glycol based electrolyte was used in the anodic oxidation process. Two-step anodic oxidation was conducted to obtain clean and open windows in TiO2 nanotube arrays. The diameter and length of the TiO2 nanotube arrays were ~ 70 nm and ~ 5 μm, respectively. The miniscrews with TiO2 nanotube arrays were implanted in the legs of New Zealand white rabbits for 8 weeks. Histological osseointegration was assessed by bone-to-implant contact ratio, and three-dimensional bone volume ratio was measured by micro-computed tomography analysis. The miniscrews with TiO2 nanotube arrays had a greater mean bone-to-implant contact ratio of 52.8 % than the control, 29.3 %. Mean bone volume ratio (BV/TV) was also higher in the miniscrews with TiO2 nanotube arrays, at 81.2 % than those in the control via micro-CT analysis. Our findings support that TiO2 nanotube arrays on the surface of miniscrews enhance osseointegration and improve the stability of the miniscrew.

Keywords

Nanotubes Orthodontic anchorage Osseointegration Bone volume micro-CT 

Notes

Acknowledgments

This research was financially supported by the Ministry of Education, Science, and Technology (MEST) and by the National Research Foundation of Korea (NRF) through the Human Resources Training Project for Regional Innovation (No. NRF-2015H1C1A1035848 and 2012H1B8A2026009).

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Insan Jang
    • 1
    • 4
  • Seong-Cheol Shim
    • 2
  • Dong-Soon Choi
    • 1
    • 4
  • Bong-Kuen Cha
    • 1
    • 4
  • Jae-Kwan Lee
    • 3
    • 4
  • Byung-Hak Choe
    • 2
    • 4
  • Won-Youl Choi
    • 2
    • 4
    Email author
  1. 1.Department of Orthodontics, College of DentistryGangneung-Wonju National UniversityGangneungSouth Korea
  2. 2.Department of Metal and Materials EngineeringGangneung-Wonju National UniversityGangneungSouth Korea
  3. 3.Department of Periodontics, College of DentistryGangneung-Wonju National UniversityGangneungSouth Korea
  4. 4.Research Institute for Dental EngineeringGangneung-Wonju National UniversityGangneungSouth Korea

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