Biomedical Microdevices

, Volume 11, Issue 3, pp 539–545

Out-of-plane microtube arrays for drug delivery—liquid flow properties and an application to the nerve block test

  • Kuniharu Takei
  • Takahiro Kawashima
  • Takeshi Kawano
  • Hidekazu Kaneko
  • Kazuaki Sawada
  • Makoto Ishida


We have proposed fabricating very fine out-of-plane silicon-dioxide microtube arrays using a selective vapor–liquid–solid (VLS) growth technique and microfabrication processes. In this study, we elucidated the liquid-flow properties of microtubes with different inner diameters. Our fabricated microtubes were 0.5 μm in wall thickness; 20 μm in height; and either 2.5 μm, 4.1 μm, 4.6 μm, or 6.4 μm in inner diameter. We determined the relationship between the flow pressure and the liquid flow rate through the microtube. We also conducted a nerve block test, in which a microtube with 4.6 μm inner diameter was used to administer lidocaine solution (Na channel blocker) to the rat sciatic nerve. This successful test represents the first reported use of a microtube for drug delivery to the peripheral nerve of a rat. We conclude that the proposed microtube array and its fabrication process might contribute to developing pharmacological devices.


Microtube Microneedle Drug delivery Vapor–liquid–solid (VLS) 


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Kuniharu Takei
    • 1
    • 5
  • Takahiro Kawashima
    • 2
  • Takeshi Kawano
    • 1
    • 4
  • Hidekazu Kaneko
    • 3
  • Kazuaki Sawada
    • 1
    • 4
  • Makoto Ishida
    • 1
    • 4
  1. 1.Department of Electrical and Electronic EngineeringToyohashi University of TechnologyToyohashiJapan
  2. 2.Department of Production Systems EngineeringToyohashi University of TechnologyToyohashiJapan
  3. 3.National Institute of Advanced Industrial Science and Technology (AIST)TsukubaJapan
  4. 4.Japan Science and Technology Agency—CRESTKawaguchiJapan
  5. 5.Japan Society for the Promotion of ScienceTokyoJapan

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