Biomedical Microdevices

, Volume 9, Issue 1, pp 61–67 | Cite as

A disposable lab-on-a-chip platform with embedded fluid actuators for active nanoliter liquid handling

  • Björn Samel
  • Volker Nock
  • Aman Russom
  • Patrick Griss
  • Göran Stemme
Article

Abstract

In this work we present the development of a disposable liquid handling lab-on-a-chip (LOC) platform with embedded actuators for applications in analytical chemistry. The proposed platform for nanoliter liquid handling is based on a thermally responsive silicone elastomer composite, consisting of PDMS and expandable microspheres. In our LOC platform, we integrate active dosing, transportation and merging of nanoliter liquid volumes. The disposable platform successfully demonstrates precise sample volume control with smart microfluidic manipulation and on-chip active microfluidic components. It is entirely fabricated from low-cost materials using wafer-level processing. Moreover, an enzymatic reaction and real-time detection was successfully conducted to exemplify its applicability as an LOC.

Keywords

Lab-on-a-chip Microfluidics Micropump PDMS composite Biochip 

Notes

Acknowledgments

The authors would like to thank Expancel (Sundsvall, Sweden) for kindly providing expandable microspheres. This work was funded by the Swedish Foundation of Strategic Research (SSF) which is greatly acknowledged.

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Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Björn Samel
    • 1
  • Volker Nock
    • 1
  • Aman Russom
    • 1
  • Patrick Griss
    • 1
  • Göran Stemme
    • 1
  1. 1.Microsystem Technology LabSchool of Electrical Engineering, Royal Institute of TechnologyStockholmSweden

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