Biomedical Microdevices

, Volume 7, Issue 4, pp 313–322

Self-Actuated, Thermo-Responsive Hydrogel Valves for Lab on a Chip

  • Jing Wang
  • Zongyuan Chen
  • Michael Mauk
  • Kuang-Sheng Hong
  • Mengyan Li
  • Shu Yang
  • Haim H. Bau
Article

DOI: 10.1007/s10544-005-6073-z

Cite this article as:
Wang, J., Chen, Z., Mauk, M. et al. Biomed Microdevices (2005) 7: 313. doi:10.1007/s10544-005-6073-z

Abstract

An easy to fabricate, thermally-actuated, self-regulated hydrogel valve for flow control in pneumatically driven, microfluidic systems is described. This microvalve takes advantage of the properties of the hydrogel, poly(N-isopropylacrylamide), as well as the aqueous fluid itself to realize flow control. The valve was designed for use in a diagnostic system fabricated with polycarbonate and aimed at the detection of pathogens in oral fluids at the location of the sample collection. The paper describes the construction and characterization of the hydrogel valves and their application for flow control, sample and reagent metering, sample distribution into multiple analysis paths, and the sealing of a polymerase chain reaction (PCR) reactor to suppress bubble formation. The hydrogel-based flow control is electronically addressable, does not require any moving parts, introduces minimal dead volume, is leakage and contaminant free, and is biocompatible.

Keywords

microvalve microfluidics hydrogel lab-on-a-chip metering distribution PCR 

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Jing Wang
    • 1
  • Zongyuan Chen
    • 1
  • Michael Mauk
    • 1
  • Kuang-Sheng Hong
    • 2
  • Mengyan Li
    • 3
  • Shu Yang
    • 2
  • Haim H. Bau
    • 1
  1. 1.Department of Mechanical Engineering and Applied MechanicsUniversity of PennsylvaniaPhiladelphia
  2. 2.Materials Science and Engineering, Chemical and Biomolecular EngineeringUniversity of PennsylvaniaPhiladelphia
  3. 3.School of Biomedical Engineering, Science and Health SystemsDrexel UniversityPhiladelphia

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