Biochemistry (Moscow)

, Volume 70, Issue 7, pp 726–729

Short-Term Regulation of the α-Ketoglutarate Dehydrogenase Complex by Energy-Linked and Some Other Effectors

  • S. Strumilo


The question of regulation of α-ketoglutarate dehydrogenase complex (KGDHC) has been considered in the biochemical literature very rarely. Moreover, such information is not usually accurate, especially in biochemical textbooks. From the mini-review of research works published during the last 25 years, the following basic view is clear: a) animal KGDHC is very sensitive to ADP, Pi, and Ca2+; b) these positive effectors increase manifold the affinity of KGDHC to α-ketoglutarate; c) KGDHC is inhibited by ATP, NADH, and succinyl-CoA; d) the ATP effect is realized in several ways, probably mainly via opposition versus ADP activation; e) NADH, besides inhibiting dihydrolipoamide dehydrogenase component competitively versus NAD+, decreases the affinity of α-ketoglutarate dehydrogenase to substrate and inactivates it; f) thioredoxin protects KGDHC from self-inactivation during catalysis; g) bacterial and plant KGDHC is activated by AMP instead of ADP. These main effects form the basis of short-term regulation of KGDHC.

Key words

α-ketoglutarate dehydrogenase 2-oxoglutarate dehydrogenase complex regulation 


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Copyright information

© MAIK “Nauka/Interperiodica” 2005

Authors and Affiliations

  • S. Strumilo
    • 1
  1. 1.Department of Animal Biochemistry, Institute of BiologyUniversity of BialystokBialystokPoland

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