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Biochemistry (Moscow)

, Volume 70, Issue 2, pp 200–214 | Cite as

Mitochondrial metabolism of reactive oxygen species

  • A. Yu. Andreyev
  • Yu. E. Kushnareva
  • A. A. Starkov
Review

Abstract

Oxidative stress is considered a major contributor to etiology of both “normal” senescence and severe pathologies with serious public health implications. Mitochondria generate reactive oxygen species (ROS) that are thought to augment intracellular oxidative stress. Mitochondria possess at least nine known sites that are capable of generating superoxide anion, a progenitor ROS. Mitochondria also possess numerous ROS defense systems that are much less studied. Studies of the last three decades shed light on many important mechanistic details of mitochondrial ROS production, but the bigger picture remains obscure. This review summarizes the current knowledge about major components involved in mitochondrial ROS metabolism and factors that regulate ROS generation and removal. An integrative, systemic approach is applied to analysis of mitochondrial ROS metabolism, which is now dissected into mitochondrial ROS production, mitochondrial ROS removal, and mitochondrial ROS emission. It is suggested that mitochondria augment intracellular oxidative stress due primarily to failure of their ROS removal systems, whereas the role of mitochondrial ROS emission is yet to be determined and a net increase in mitochondrial ROS production in situ remains to be demonstrated.

Key words

mitochondria reactive oxygen species superoxide antioxidants oxidative stress 

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Copyright information

© MAIK “Nauka/Interperiodica” 2005

Authors and Affiliations

  • A. Yu. Andreyev
    • 1
    • 2
  • Yu. E. Kushnareva
    • 1
    • 3
  • A. A. Starkov
    • 1
    • 4
  1. 1.Alumni of Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State UniversityMoscowRussia
  2. 2.University of CaliforniaSan Diego, La JollaUSA
  3. 3.The Burnham InstituteDel E. Webb Center for Neuroscience and AgingLa JollaUSA
  4. 4.Weill Medical College Cornell UniversityNew YorkUSA

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