Mutationism, not Lamarckism, captures the novelty of CRISPR–Cas
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Koonin, in an article in this issue, claims that CRISPR–Cas systems are mechanisms for the inheritance of acquired adaptive characteristics, and that the operation of such systems comprises a “Lamarckian mode of evolution.” We argue that viewing the CRISPR–Cas mechanism as facilitating a form of “directed mutation” more accurately represents how the system behaves and the history of neoDarwinian thinking, and is to be preferred.
KeywordsLamarckian Evolution CRISPR–Cas Directed mutation Mutationism
Funding was provided by Natural Sciences and Engineering Research Council of Canada (Grant No. GLDSU447989).
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