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BioMetals

pp 1–11 | Cite as

Exposure routes and health effects of heavy metals on children

  • Muwaffak Al osman
  • Fei YangEmail author
  • Isaac Yaw Massey
Article
  • 101 Downloads

Abstract

Heavy metals are naturally existing elements that have relatively high atomic weight and a minimum density five times the density of water. Heavy metals have extensive applications in industries, homes, agriculture and medicine, leading to their wide distribution in the environment. Most heavy metals are reported to be highly toxic. They also have numerous exposure routes, including ingestion, inhalation, and dermal absorption, subsequently inducing some health effects resulting from human and heavy metals contact. The implications of heavy metals with regards to children’s health have been noted to be more severe compared to adults. The element’s harmful consequences on children health include mental retardation, neurocognitive disorders, behavioral disorders, respiratory problems, cancer and cardiovascular diseases. Much attention should be given to heavy metals because of their high toxicity potential, widespread use, and prevalence. This review therefore examines the exposure routes and health effects of mercury (Hg), lead (Pb), chromium (Cr), cadmium (Cd), and barium (Ba) on children. In addition, their toxic mechanisms are elucidated.

Keywords

Mercury (Hg) Lead (Pb) Chromium (Cr) Cadmium (Cd) Barium (Ba) Health effects Exposure routes Mechanisms of toxicity 

Notes

Acknowledgements

This work was supported by National Natural Science Foundation (81502787, 81773393), Central South University Innovation Driven Project (20170027010004), Key Research and Development Projects in Hunan Province (2018WK2013), and National key research and development program of China (2016YFC0900800).

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest.

References

  1. Aaseth J, Ajsuvakova O, Skalny A, Skalnaya M, Tinkov A (2018) Chelator combination as therapeutic strategy in mercury and lead poisonings. Coord Chem Rev 358:1–12.  https://doi.org/10.1016/j.ccr.2017.12.011 Google Scholar
  2. Absalon D, Ślesak B (2010) The effects of changes in cadmium and lead air pollution on cancer incidence in children. Sci Total Environ 408(20):4420–4428Google Scholar
  3. Beaumont JJ, Sedman RM, Reynolds SD, Sherman CD, Li LH, Howd RA, Sandy MS, Zeise L, Alexeeff GV (2008) Cancer mortality in a Chinese population exposed to hexavalent chromium in drinking water. Epidemiology 19(1):12–23Google Scholar
  4. Beckley AL, Caspi A, Broadbent J (2018) Association of childhood blood lead levels with criminal offending. JAMA Pediatr 172(2):166–173.  https://doi.org/10.1001/jamapediatrics.2017.4005 Google Scholar
  5. Berlin M, Zalups RK, Fowler BA (2015) Mercury. Handbook on the toxicology of metals, pp 1013–1075.  https://doi.org/10.1016/b978-0-444-59453-2.00046-9
  6. Boonprasert K, Vesey DA, Gobe GC, Ruenweerayut R, Johnson DW, Na-Bangchang K, Satarug S (2018) Is renal tubular cadmium toxicity clinically relevant? Clin Kidney J.  https://doi.org/10.1093/ckj/sfx153 Google Scholar
  7. Broussard LA, Ph D, Hammett-Stabler CA, Ph D, Winecker RE, Jeri P, Ropero-Miller D, Ph D (2002) The toxicology of mercury. Lab Med 33(8):614–625Google Scholar
  8. Buters J, Biedermann T (2017) Chromium (VI) contact dermatitis: getting closer to understanding the underlying mechanisms of toxicity and sensitization! J Investig Dermatol 137(2):274–277Google Scholar
  9. Cai L-M, Wang Q-S, Luo J, Chen L-G, Zhu R-L, Wang S, Tang C-H (2019) Heavy metal contamination and health risk assessment for children near a large Cu-smelter in central China. Sci Total Environ 650:725–733.  https://doi.org/10.1016/j.scitotenv.2018.09.081 Google Scholar
  10. Calabresea E, Iavicoli I, Calabrese V, Cory-Slechtad D, Giordanoe J (2018) Elemental mercury neurotoxicity and clinical recovery of function: a review of findings, and implications for occupational health. Environ Res 163:134–148.  https://doi.org/10.1016/j.envres.2018.01.021 Google Scholar
  11. Centre for Disease Control (2007) Medical Management Guidelines (MMGs): Barium. Retrieved from https://www.atsdr.cdc.gov/MMG/MMG.asp?id=321&tid=57
  12. Centre for Disease Control (2013) Chromium toxicity what are the physiologic effects of chromium exposure. https://www.atsdr.cdc.gov
  13. Centre for Disease Control (2015) Low level lead exposure harms children: a renewed call for primary prevention. https://www.cdc.gov
  14. Chunhabundit R (2016) Cadmium exposure and potential health risk from foods in a contaminated area, Thailand. Toxicol Res 32(1):65–72.  https://doi.org/10.5487/TR.2016.32.1.065 Google Scholar
  15. Dayan AD, Paine AJ (2001) Mechanisms of chromium toxicity, carcinogenicity and allergenicity: review of the literature from 1985 to 2000. Hum Exp Toxicol 20(9):439–451.  https://doi.org/10.1191/096032701682693062 Google Scholar
  16. Dietrich KN, Douglas RM, Succopa PA, Berger OG, Bornscheina RL (2001) Early exposure to lead and juvenile delinquency. Neurotoxicol Teratol 23(6):511–518Google Scholar
  17. Díez S, Delgado S, Aguilera I, Astray J, Pérez-Gómez B, Torrent M, Sunyer J, Bayona JM (2009) Prenatal and early childhood exposure to mercury and methylmercury in Spain, a high-fish-consumer country. Arch Environ Contam Toxicol 56(3):615–622Google Scholar
  18. Do SY, Lee CG, Kim JY, Moon YH, Kim MS, Bae IH, Song HS (2017) Cases of acute mercury poisoning by mercury vapor exposure during the demolition of a fluorescent lamp factory. Ann Occup Environ Med 29:19.  https://doi.org/10.1186/s40557-017-0184-x Google Scholar
  19. Evens A, Hryhorczuk D, Lanphear BP, Rankin KM, Lewis KA, Forst L, Rosenberg D (2015) The impact of low-level lead toxicity on school performance among children in the Chicago Public Schools: a population-based retrospective cohort study. Environ Health.  https://doi.org/10.1186/s12940-015-0008-9 Google Scholar
  20. Feigenbaum JJ, Muller C (2016) Lead exposure and violent crime in the early twentieth century. Explor Econ Hist 62:51–86.  https://doi.org/10.1016/j.eeh.2016.03.002 Google Scholar
  21. Fergusson DM, Boden JM, Horwood LJ (2008) Exposure to childhood sexual and physical abuse and adjustment in early adulthood. Child Abuse Negl 32(6):607–619Google Scholar
  22. Flora G, Gupta D, Tiwari A (2012) Toxicity of lead: a review with recent updates. Interdiscip Toxicol 5(2):47–58.  https://doi.org/10.2478/v10102-012-0009-2 Google Scholar
  23. Gardner RM, Kippler M, Tofail F, Bottai M, Hamadani J, Grandér M, Nermell B, Palm B, Rasmussen K, Vahter M (2013) Environmental exposure to metals and children’s growth to age 5 years: a prospective cohort study. Am J Epidemiol 177(12):1356–1367.  https://doi.org/10.1093/aje/kws437 Google Scholar
  24. Goyer RA, Liu J, Waalkes MP (2004) Cadmium and cancer of prostate and testis. Biometals 17(5):555–558Google Scholar
  25. Habiba G, Abebe G, Bravo AG, Ermias D, Staffan Ǻ, Bishop K (2017) Mercury human exposure in populations living around Lake Tana (Ethiopia). Biol Trace Elem Res 175(2):237–243Google Scholar
  26. Halasova E, Matakova T, Kavcova E, Musak L, Letkova L, Adamkov M, Ondrusova M, Bukovska E, Singliar A (2009) Human lung cancer and hexavalent chromium exposure. Neuro Endocrinol Lett 30:182–185Google Scholar
  27. Hamzah NA, MohdTamrin SB, Ismail NH (2016) Metal dust exposure and lung function deterioration among steelworkers: an exposure-response relationship. Int J Occup Environ Health 22(3):224–232Google Scholar
  28. Hartwig A (2013) Cadmium and cancer. In: Sigel A, Sigel H, Sigel R (eds) Cadmium: from toxicity to essentiality. Springer, Dordrecht, pp 491–507Google Scholar
  29. He K, Wang S, Zhang J (2009) Blood lead levels of children and its trend in China. Sci Total Environ 407(13):3986–3993.  https://doi.org/10.1016/j.scitotenv.2009.03.018 Google Scholar
  30. Hong SB, Im MH, Kim JW, Park EJ, Shin MS, Kim BN, Yoo HJ et al (2015) Environmental lead exposure and attention-deficit/hyperactivity disorder symptom domains in a community sample of South Korean school-age children. Environ Health Perspect 123(3):271Google Scholar
  31. Huang X, Law S, Li D, Xin Yu, Li B (2014) Mercury poisoning: a case of a complex neuropsychiatric illness. Am J Psychiatry 171(12):1253–1256Google Scholar
  32. Jeon JY, Ha KH, Kim DJ (2015) New risk factors for obesity and diabetes: environmental chemicals. J Diabetes Invest 6(2):109–111Google Scholar
  33. Jeppesen C, Valera B, Nielsen NO, Bjerregaard P, Jørgensen ME (2015) Association between whole blood mercury and glucose intolerance among adult Inuit in Greenland. Environ Res 143:192–197Google Scholar
  34. Jia G, Aroor AR, Martinez-Lemus LA, Sowers JR (2015) Mitochondrial functional impairment in response to environmental toxins in the cardiorenal metabolic syndrome. Arch Toxicol 89(2):147–153Google Scholar
  35. Kampa M, Castanas E (2008) Human health effects of air pollution. Environ Pollut 151(2):362–367Google Scholar
  36. Kaur S, Kaur A, Singh G, Bhatti R (2018) Mercurius solubilis attenuates scopolamine-induced memory deficits and enhances the motor coordination in mice. Int J Neurosci 128(3):219–230Google Scholar
  37. Kim K-N, Kwon H-J, Hong Y-C (2016) Low-level lead exposure and autistic behaviors in school-age children. Neurotoxicology 53:193–200Google Scholar
  38. Kippler M, Tofail F, Hamadani JD, Gardner RM, Grantham-McGregor SM, Bottai M, Vahter M (2012) Early-Life cadmium exposure and child development in 5-year-old girls and boys: a cohort study in rural Bangladesh. Environ Health Perspect 120(10):1462–1468.  https://doi.org/10.1289/ehp.1104431 Google Scholar
  39. Lanphear BP, Hornung R, Khoury J, Yolton K, Baghurst P, Bellinger DC, Canfield RL et al (2005) Low-level environmental lead exposure and children’s intellectual function: an international pooled analysis. Environ Health Perspect 113(7):894Google Scholar
  40. Liu Y, McDermott S, Lawson A, Aelion CM (2010) The relationship between mental retardation and developmental delays in children and the levels of arsenic, mercury and lead in soil samples taken near their mother’s residence during pregnancy. Int J Hyg Environ Health 213(2):116–123Google Scholar
  41. Mahmud HN, Huq AK, Yahya R (2016) The removal of Heavy metals ions from wastewater/aqueous solution using polypyrrole-based adsorbents: a review. RSC Adv 6(18):14778–14791Google Scholar
  42. Mason LH, Harp JP, Han DY (2014) Pb neurotoxicity: neuropsychological effects of lead toxicity. BioMed Res Int 2014:840547–840547.  https://doi.org/10.1155/2014/840547 Google Scholar
  43. Meyer M, Rogers C (2018) The relationship between exposure to lead and criminal behaviorGoogle Scholar
  44. Mohamed FE, Zaky EA, El-Sayed AB, Elhossieny RM, Zahra SS, Eldin WS, Youssef WY, Khaled RA, Youssef AM (2015) Assessment of hair aluminum, lead, and mercury in a sample of autistic Egyptian children: environmental risk factors of Heavy metals in autism. Behav Neurol 2:4.  https://doi.org/10.1155/2015/545674 Google Scholar
  45. Myers GJ, Thurston SW, Pearson AT, Davidson PW, Cox C, Shamlaye CF, Cernichiari E, Clarkson TW (2009) Postnatal exposure to methyl mercury from fish consumption: a review and new data from the Seychelles Child Development Study. Neurotoxicology 30(3):338–349Google Scholar
  46. Navas-Acien A, Selvin E, Sharrett AR, Calderon-Aranda E, Silbergeld E, Guallar E (2004) Lead, cadmium, smoking, and increased risk of peripheral arterial disease. Circulation 109(25):3196–3201Google Scholar
  47. Nawrot T, Plusquin M, Hogervorst J, Roels HA, Celis H, Thijs L, Vangronsveld J, Van Hecke E, Staessen JA (2006) Environmental exposure to cadmium and risk of cancer: a prospective population-based study. Lancet Oncol 7(2):119–126Google Scholar
  48. Neghab M, Azad P, Zarei F, Ghaderi E (2015) Acute and chronic respiratory effects of chromium mists. J Health Sci Surveill Syst 3(3):119–124Google Scholar
  49. Nemsadze K, Sanikidze T, Ratiani L, Gabunia L, Sharashenidze T (2009) Mechanisms of lead-induced poisoning. Georgian Med News 172–173:92–96Google Scholar
  50. Oken E, Bellinger DC (2008) Fish consumption, methylmercury and child neurodevelopment. Curr Opin Pediatr 20(2):178Google Scholar
  51. Olympio KPK, da Silva JP, da Silva AS, Souza VC, Buzalaf MA, Barbosa F, Cardoso MR (2018) Blood lead and cadmium levels in preschool children and associated risk factors in São Paulo, Brazil. Environ Pollut 240:831–838.  https://doi.org/10.1016/j.envpol.2018.04.124 Google Scholar
  52. Pfadenhauer LM, Burns J, Rohwer A, Rehfuess EA (2014) A protocol for a systematic review of the effectiveness of interventions to reduce exposure to lead through consumer products and drinking water. Syst Rev 3(1):36Google Scholar
  53. Prozialeck WC, Edwards JR (2012) Mechanisms of cadmium-induced proximal tubule injury: new insights with implications for biomonitoring and therapeutic interventions. J Pharmacol Exp Ther 343(1):2–12Google Scholar
  54. Ramzan M, Malik MA, Iqbal Z, Arshad N, Khan SY, Arshad M (2011) Study of hematological indices in tannery workers exposed to chromium in Sheikhupura (Pakistan). Toxicol Ind Health 27(9):857–864Google Scholar
  55. Rani A, Kumar A, Lal A, Pant M (2014) Cellular mechanisms of cadmium-induced toxicity: a review. Int J Environ Health Res 24(4):378–399Google Scholar
  56. Rasoul GMA, Salem ME, Allam HK, Kasemy ZA, Younis FE (2017) Health-related disorders on occupational exposure to chromium in a leather tanning factory (Menoufia, Egypt). Menoufia Med J 30(1):92Google Scholar
  57. Ray RR (2016) Adverse hematological effects of hexavalent chromium: an overview. Interdiscip Toxicol 9(2):55–65Google Scholar
  58. Reuben A, Caspi A, Belsky DW, Broadbent J, Harrington H, Sugden K, Houts RM, Ramrakha S, Poulton R, Moffitt TE (2017) Association of childhood blood lead levels with cognitive function and socioeconomic status at age 38 years and with IQ change and socioeconomic mobility between childhood and adulthood. JAMA 317(12):1244–1251Google Scholar
  59. Reyes JW (2015) Lead exposure and behavior: effects on antisocial and risky behavior among children and adolescents. Econ Inq 53:1580–1605.  https://doi.org/10.1111/ecin.12202 Google Scholar
  60. Rice KM, Walker EM, Wu M, Gillette C, Blough ER (2014) Environmental mercury and its toxic effects. J Prev Med Public Health 47(2):74Google Scholar
  61. Rodrigues EG, Bellinger DC, Valeri L, Hasan MO, Quamruzzaman Q, Golam M, Kile ML, Christiani DC, Wright RO, Mazumdar M (2016) Neurodevelopmental outcomes among 2-to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water. Environ Health 15(1):44Google Scholar
  62. Roy A, Bellinger D, Howard H, Schwartz J, Ettinger AS, Wright RO, Bouchard M, Palaniappan K, Balakrishnan K (2009) Lead exposure and behavior among young children in Chennai, India. Environ Health Perspect 117(10):1607Google Scholar
  63. Safhi MM, Khuwaja G, Alam MF, Hussain S, Siddiqui MH, Islam F (2016) Cadmium-induced nephrotoxicity via oxidative stress in male wistar rats and capsaicin protects its toxicity. Bull Environ Pharmacol Life Sci 5:5–11Google Scholar
  64. Sagiv SK, Thurston SW, Bellinger DC, Amarasiriwardena C, Korrick SA (2012) Prenatal exposure to mercury and fish consumption during pregnancy and attention-deficit/hyperactivity disorder–related behavior in children. Arch Pediatr Adolesc Med 166(12):1123–1131Google Scholar
  65. Saha R, Nandi R, Saha B (2011) Sources and toxicity of hexavalent chromium. J Coord Chem 64(10):1782–1806Google Scholar
  66. Sampson JR, Winter SA (2018) Poisoned development: assessing childhood lead exposure as a cause of crime in a birth cohort followed through adolescence. Criminology 56:269–301.  https://doi.org/10.1111/1745-9125.12171 Google Scholar
  67. Sawut R, Kasim N, Maihemuti B, Hu L, Abliz A, Abdujappar A, Kurban M (2018) Pollution characteristics and health risk assessment of heavy metals in the vegetable bases of northwest China. Sci Total Environ 642:864–878.  https://doi.org/10.1016/j.scitotenv.2018.06.034 Google Scholar
  68. Schoeters G, Hond ED, Zuurbier M, Naginiene R, Hazel P, Stilianakis N, Ronchetti R, Koppe JG (2006) Cadmium and children: exposure and health effects. Acta Paediatr 95:50–54Google Scholar
  69. Schumacher L, Abbott LC (2017) Effects of methylmercury exposure on pancreatic beta cell development and function. J Appl Toxicol 37(1):4–12Google Scholar
  70. Sharma BK, Singhal PC, Chugh KS (1978) Intravascular haemolysis and acute renal failure following potassium dichromate poisoning. Postgrad Med J 54(632):414–415Google Scholar
  71. Shelnutt S, Goad P, Belsito D (2007) Dermatological toxicity of hexavalent chromium. Crit Rev Toxicol 37(5):375–387Google Scholar
  72. Sherief LM, Abdelkhalek ER, Gharieb AF, Sherbiny HS, Usef DM, Almalky AA, Kamal NM, Salama MA, Gohar W (2015) Cadmium status among pediatric cancer patients in egypt. Medicine 94(20):e740Google Scholar
  73. Skerfving S, Löfmark L, Lundh T, Mikoczy Z, Strömberg U (2015) Late effects of low blood lead concentrations in children on school performance and cognitive functions. Neurotoxicology 49:114–120.  https://doi.org/10.1016/j.neuro.2015.05.009 Google Scholar
  74. Streets DG, Horowitz HM, Jacob DJ, Lu Z, Levin L, Ter Schure AF, Sunderland EM (2017) Total mercury released to the environment by human activities. Environ Sci Technol 51(117):5969–5977Google Scholar
  75. Sughis M, Penders J, Haufroid V, Nemery B, Nawrot TS (2011) Bone resorption and environmental exposure to cadmium in children: a cross-sectional study. Environ Health 10(1):104Google Scholar
  76. Takaki A, Jimi S, Segawa M, Hisano S, Takebayashi S, Iwasaki H (2004) Long-term cadmium exposure accelerates age-related mitochondrial changes in renal epithelial cells. Toxicology 203(1–3):145–154Google Scholar
  77. Tang Y, Wang X, Jia J (2015) Mercury poisoning presenting as sporadic Creutzfeldt-Jakob disease: a case report. Ann Intern Med 162(6):462–463Google Scholar
  78. Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ (2012) Heavy metals toxicity and the environment. EXS 101:133–164.  https://doi.org/10.1007/978-3-7643-8340-4_6 Google Scholar
  79. Tellez-Plaza M, Guallar E, Howard BV, Umans JG, Francesconi KA, Goessler W, Silbergeld EK, Devereux RB, Navas-Acien A (2013) Cadmium exposure and incident cardiovascular disease.”. Epidemiology 24(3):421Google Scholar
  80. Tepanosyan G, Sahakyan L, Belyaeva O, Asmaryan S, Saghatelyan A (2018) Continuous impact of mining activities on soil heavy metals levels and human health. Sci Total Environ 639:900–909.  https://doi.org/10.1016/j.scitotenv.2018.05.211 Google Scholar
  81. Wallin A, Di Giuseppe D, Orsini N, Åkesson A, Forouhi NG, Wolk A (2017) Fish consumption and frying of fish in relation to type 2 diabetes incidence: a prospective cohort study of Swedish men. Eur J Nutr 56(2):843–852Google Scholar
  82. Wilbur S, Abadin H, Fay M, Yu D, Tencza B, Ingerman L, Klotzbach J, James S, Agency for Toxic Substances and Disease Registry (ATSDR) (2012) Toxicological profile for carbon monoxide. Agency for Toxic Substances and Disease Registry (US), AtlantaGoogle Scholar
  83. Wright JP, Dietrich KN, Douglas Ris M, Hornung RW, Wessel SD, Lanphear BP, Ho M, Rae MN (2008) Association of prenatal and childhood blood lead concentrations with criminal arrests in early adulthood. PLoS Med 5(5):e101Google Scholar
  84. Wu W, Wu P, Yang F, Sun D, Zhang D-X, Zhou Y-K (2018) Assessment of heavy metal pollution and human health risks in urban soils around an electronics manufacturing facility. Sci Total Environ 630:53–61.  https://doi.org/10.1016/j.scitotenv.2018.02.183 Google Scholar
  85. Xie J, Shaikh ZA (2006) Cadmium-induced apoptosis in rat kidney epithelial cells involves decrease in nuclear factor-kappa B activity. Toxicol Sci 91(1):299–308Google Scholar
  86. Agency for Toxic Substances and Disease Registry (n.d.). Chromium (Cr) toxicity: what are the physiologic effects of chromium exposure? Environmental Medicine & Environmental Health Education—CSEM. Retrieved from https://www.atsdr.cdc.gov/csem/csem.asp?csem=10&po=10
  87. Ye BS, Leung AOW, Wong MH (2017) The association of environmental toxicants and autism spectrum disorders in children. Environ Pollut 227:234–242Google Scholar
  88. Yoshihisa Y, Shimizu T (2012) Metal allergy and systemic contact dermatitis: an overview. Dermatol Res Pract.  https://doi.org/10.1155/2012/749561 Google Scholar
  89. Zhitkovich A (2011) Chromium in drinking water: sources, metabolism, and cancer risks. Chem Res Toxicol 24(10):1617–1629Google Scholar
  90. Zhou Z, Zhang X, Cui F, Liu R, Dong Z, Wang X, Shengyuan Yu (2014) Subacute motor neuron hyperexc itability with mercury poisoning: a case series and literature review. Eur Neurol 72(3–4):218–222Google Scholar

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© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Occupational and Environmental Health, Xiangya School of Public HealthCentral South UniversityChangshaChina
  2. 2.Key Laboratory of Biometallurgy, Ministry of Education, School of Mineral Processing and BioengineeringCentral South UniversityChangshaChina
  3. 3.Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public HealthSoutheast UniversityNanjingChina

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