In vivo effect of copper status on cisplatin-induced nephrotoxicity
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Cisplatin is a widely used antitumor agent; however, tumor resistance and severe side effects limit its use. It is well accepted that cisplatin toxicity can be modulated in vitro in cell cultures by copper salts. In the present work, mice with different blood serum copper status were treated with a single intraperitoneal cisplatin injection at a dose of 5 mg/kg, monitored for 3 days in metabolic cages and analyzed for renal function. Both copper-deficient and copper-overloaded mice displayed more severe early proteinuria and retarded platinum excretion than control mice. The effects of copper status on cisplatin-induced nephrotoxicity are discussed.
KeywordsCisplatin Nephrotoxicity Murine model of copper status
The work was supported by a CARIPLO Foundation fellowship grant (to LP) and support from the Russian Foundation for Basic Research (15-04-06770a to LP, 16-34-60219 to EI). We also gratefully acknowledge the generous contribution of the Italian Association for Cancer Research (AIRC; to MB).