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BioMetals

, Volume 28, Issue 3, pp 509–519 | Cite as

Host-imposed manganese starvation of invading pathogens: two routes to the same destination

  • Jacqueline R. Morey
  • Christopher A. McDevitt
  • Thomas E. Kehl-Fie
Article

Abstract

During infection invading pathogens must acquire all essential nutrients, including first row transition metals, from the host. To combat invaders, the host exploits this fact and restricts the availability of these nutrients using a defense mechanism known as nutritional immunity. While iron sequestration is the most well-known aspect of this defense, recent work has revealed that the host restricts the availability of other essential elements, notably manganese (Mn), during infection. Furthermore, these studies have revealed that the host utilizes multiple strategies that extend beyond metal sequestration to prevent bacteria from obtaining these metals. This review will discuss the mechanisms by which bacteria attempt to obtain the essential first row transition metal ion Mn during infection, and the approaches utilized by the host to prevent this occurrence. In addition, this review will discuss the impact of host-imposed Mn starvation on invading bacteria.

Keywords

ABC transporter Manganese Zinc Nutritional immunity Calprotectin Infection 

Notes

Acknowledgments

We apologize to our colleagues whose work we were unable to cite due to length restrictions. J.R.M. is supported by an Australian Postgraduate Award. This work was supported by the Australian Research Council Grants DP120103957 and DP150104515 to C.A.M., the National Health and Medical Research Council Project Grants 1022240 and 1080784 to C.A.M., and a K22 AI104805 from the National Institutes of Health as well as by Research Grant No. 5-FY15-30 from the March of Dimes Foundation to T.E.K. This work is solely the responsibility of the authors and does not reflect the views of the National Institutes of Health.

Conflict of interest

The authors declare no competing financial interests.

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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Research Centre for Infectious Diseases, School of Molecular and Biomedical ScienceUniversity of AdelaideAdelaideAustralia
  2. 2.Department of MicrobiologyUniversity of Illinois Urbana-ChampaignUrbanaUSA

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