BioMetals

, Volume 26, Issue 3, pp 465–471

Chelation of chromium(VI) by combining deferasirox and deferiprone in rats

  • Marzieh Iranmanesh
  • S. Jamil A. Fatemi
  • Roza Ebrahimpour
  • Faezeh Dahooee Balooch
Article

DOI: 10.1007/s10534-013-9631-5

Cite this article as:
Iranmanesh, M., Fatemi, S.J.A., Ebrahimpour, R. et al. Biometals (2013) 26: 465. doi:10.1007/s10534-013-9631-5

Abstract

The present research is aimed to characterize the potential efficiency of two chelators after chromium(VI) administration for 60 days following two doses of 15 and 30 mg/kg chromium(VI) per body weight daily to male rats. However, the hypothesis that the two chelators might be more efficient as combined therapy than as single therapy in removing chromium(VI) from rat organs was considered. In this way, two known chelators deferasirox and deferiprone were chosen and given orally as a single or combined therapy for a period of 1 week. Chromium(VI) and iron concentrations in tissues were determined by flame atomic absorption spectroscopy. The combined chelation therapy results show that deferasirox and deferiprone are able to remove chromium(VI) ions from various tissues while iron concentration returned to normal levels and symptoms also decreased.

Keywords

Deferasirox Deferiprone Chromium toxicity Chelation therapy Rats 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Marzieh Iranmanesh
    • 1
  • S. Jamil A. Fatemi
    • 1
  • Roza Ebrahimpour
    • 1
  • Faezeh Dahooee Balooch
    • 1
  1. 1.Chemistry DepartmentShahid Bahonar University of KermanKermanIran

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