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BioMetals

, Volume 25, Issue 4, pp 761–776 | Cite as

Iron toxicity in neurodegeneration

  • Marco T. Núñez
  • Pamela Urrutia
  • Natalia Mena
  • Pabla Aguirre
  • Victoria Tapia
  • Julio Salazar
Article

Abstract

Iron is an essential element for life on earth, participating in a plethora of cellular processes where one-electron transfer reactions are required. Its essentiality, coupled to its scarcity in aqueous oxidative environments, has compelled living organisms to develop mechanisms that ensure an adequate iron supply, at times with disregard to long-term deleterious effects derived from iron accumulation. However, iron is an intrinsic producer of reactive oxygen species, and increased levels of iron promote neurotoxicity because of hydroxyl radical formation, which results in glutathione consumption, protein aggregation, lipid peroxidation and nucleic acid modification. Neurons from brain areas sensitive to degeneration accumulate iron with age and thus are subjected to an ever increasing oxidative stress with the accompanying cellular damage. The ability of these neurons to survive depends on the adaptive mechanisms developed to cope with the increasing oxidative load. Here, we describe the chemical and thermodynamic peculiarities of iron chemistry in living matter, review the components of iron homeostasis in neurons and elaborate on the mechanisms by which iron homeostasis is lost in Parkinson’s disease, Alzheimer’s disease and other diseases in which iron accumulation has been demonstrated.

Keywords

Iron homeostasis Mitochondria dysfunction GSH Fe–S clusters Neurodegeneration 

Notes

Acknowledgments

This work was financed by grant 1100599 from Fondo Nacional de Ciencia y Tecnología Chile, (FONDECYT) and by project ICM-P05-001-F from the Millennium Scientific Initiative, Ministerio de Economía, Chile.

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Copyright information

© Springer Science+Business Media, LLC. 2012

Authors and Affiliations

  • Marco T. Núñez
    • 1
  • Pamela Urrutia
    • 1
  • Natalia Mena
    • 1
  • Pabla Aguirre
    • 1
  • Victoria Tapia
    • 1
  • Julio Salazar
    • 1
  1. 1.Department of Biology, Faculty of SciencesUniversidad de Chile and Cell Dynamics and Biotechnology InstituteSantiagoChile

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