BioMetals

, Volume 25, Issue 2, pp 337–350

Transition metal abnormalities in progressive dementias

  • Hiroyasu Akatsu
  • Akira Hori
  • Takayuki Yamamoto
  • Mari Yoshida
  • Maya Mimuro
  • Yoshio Hashizume
  • Ikuo Tooyama
  • Eric M. Yezdimer
Article

Abstract

Abnormal distributions of transition metals inside the brain are potential diagnostic markers for several central nervous system diseases, including Alzheimer’s disease (AD), Parkinson’s disease, dementia with Lewy bodies (DLB), bipolar disorders and depression. To further explore this possibility, the total concentrations of iron, zinc, copper, manganese, aluminum, chromium and cadmium were measured in post-mortem hippocampus and amygdala tissues taken from AD, DLB and Control patients. A statistically significant near fifty percent reduction in the total copper levels of AD patients was observed in both the hippocampus and amygdala. The statistical power of the hippocampus and amygdala copper analysis was found to be 86 and 74% respectively. No statistically significant deviations in the total metal concentrations were found for zinc, manganese, chromium or aluminum. Iron was found to be increased by 38% in AD amygdala tissues, but was unchanged in AD hippocampus tissues. Accounting for differences in tissue water content, as a function of both tissue type and disease state, revealed more consistencies with previous literature. To aid in the design of future experiments, the effect sizes for all tissue types and metals studied are also presented.

Keywords

Copper Iron Alzheimer’s disease Lewy body Amygdala Hippocampus 

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Hiroyasu Akatsu
    • 1
  • Akira Hori
    • 1
  • Takayuki Yamamoto
    • 1
  • Mari Yoshida
    • 2
  • Maya Mimuro
    • 2
  • Yoshio Hashizume
    • 1
  • Ikuo Tooyama
    • 3
  • Eric M. Yezdimer
    • 4
    • 5
  1. 1.Choju Medical Institute, Fukushimura HospitalToyohashiJapan
  2. 2.Department of NeuropathologyInstitute for Medical Science of Aging, Aichi Medical UniversityNagakuteJapan
  3. 3.Research Promotion Organization for Intractable Neurological Disease, Molecular Neuroscience Research Center, Shiga Medical UniversityOtsuJapan
  4. 4.State CollegeUSA
  5. 5.Industrial Summit TechnologyParlinUSA

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