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BioMetals

, Volume 22, Issue 4, pp 557–564 | Cite as

Siderocalins: siderophore-binding proteins of the innate immune system

  • Matthew C. Clifton
  • Colin Corrent
  • Roland K. StrongEmail author
Article

Abstract

Recent studies have revealed that the mammalian immune system directly interferes with siderophore-mediated iron acquisition through siderophore-binding proteins and that the association of certain siderophores, or siderophore modifications, with virulence is a direct response of pathogens to evade these defenses.

Keywords

Siderophores Siderophore-binding proteins Bacterial virulence Bacterial iron acquisition Innate immunity 

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Copyright information

© Springer Science+Business Media, LLC. 2009

Authors and Affiliations

  • Matthew C. Clifton
    • 1
  • Colin Corrent
    • 1
  • Roland K. Strong
    • 1
    Email author
  1. 1.Division of Basic SciencesFred Hutchinson Cancer Research CenterSeattleUSA

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