Siderocalins: siderophore-binding proteins of the innate immune system
- 348 Downloads
Recent studies have revealed that the mammalian immune system directly interferes with siderophore-mediated iron acquisition through siderophore-binding proteins and that the association of certain siderophores, or siderophore modifications, with virulence is a direct response of pathogens to evade these defenses.
KeywordsSiderophores Siderophore-binding proteins Bacterial virulence Bacterial iron acquisition Innate immunity
- Holmes MA, Paulsene W, Jide X et al (2005) Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration. Struct Camb 13(1):29–41Google Scholar
- Meilinger M, Haumer M, Szakmary KA et al (1995) Removal of lactoferrin from plasma is mediated by binding to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor and transport to endosomes. FEBS Lett 360(1):70–74. doi: 10.1016/0014-5793(95)00082-K PubMedCrossRefGoogle Scholar
- Raymond KN, Müller G, Matzanke BF (1984) Complexation of iron by siderophores. a review of their solution and structural chemistry and biological function. In: Boschke FL (ed) Topics in current chemistry, vol 123. Springer, Berlin, pp 50–102Google Scholar