Iron acquisition by Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis
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The bacterium Pseudomonas aeruginosa is commonly isolated from the general environment and also infects the lungs of patients with cystic fibrosis (CF). Iron in mammals is not freely available to infecting pathogens although significant amounts of extracellular iron are available in the sputum that occurs in the lungs of CF patients. P. aeruginosa has a large number of systems to acquire this essential nutrient and many of these systems have been characterised in the laboratory. However, which iron acquisition systems are active in CF is not well understood. Here we review recent research that sheds light on how P. aeruginosa obtains iron in the lungs of CF patients.
KeywordsPseudomonas aeruginosa Chronic infection Cystic fibrosis Iron acquisition Siderophore Pyoverdine Pyochelin Infectious disease
We acknowledge with appreciation the excellent work of many researchers in this field that for reasons of space could not be cited here. Our research is supported by grants from the Australian National Health and Medical Research Council and the Australian Cystic Fibrosis Trust. AK is a recipient of a New Zealand Bright Futures PhD scholarship.
- Cao J, Woodhall MR, Alvarez J, Cartron ML, Andrews SC (2007) EfeUOB (YcdNOB) is a tripartite, acid-induced and CpxAR-regulated, low-pH Fe2+ transporter that is cryptic in Escherichia coli K-12 but functional in E. coli O157:H7. Mol Microbiol 65:857–875. doi:10.1111/j.1365-2958.2007.05802.x PubMedCrossRefGoogle Scholar
- De Vos D et al (2001) Study of pyoverdine type and production by Pseudomonas aeruginosa isolated from cystic fibrosis patients: prevalence of type II pyoverdine isolates and accumulation of pyoverdine-negative mutations. Arch Microbiol 175:384–388. doi:10.1007/s002030100278 PubMedCrossRefGoogle Scholar
- Haas B, Murphy E, Castignetti D (1991b) Siderophore synthesis by mucoid Pseudomonas aeruginosa strains isolated from cystic fibrosis patients. J Microbiol 37:654, 657Google Scholar
- Konstan MW et al. (2007) Risk factors for rate of decline in forced expiratory volume in one-second in children and adolescents with cystic fibrosis. J Pediatr 151:134–139, 139.e1Google Scholar
- Matzanke BF (2005) Iron transport: siderophores. In: King RB (ed) Encyclopedia of Inorganic Chemistry, 2nd edn. Wiley, New YorkGoogle Scholar
- Meyer J-M, Abdallah MA (1978) The fluorescent pigment of Pseudomonas fluorescens: biosynthesis, purification and physicochemical properties. J Gen Microbiol 107:319–328Google Scholar
- Musk DJJ, Hergenrother PJ (2008) Chelated iron sources are inhibitors of Pseudomonas aeruginosa biofilms and distribute efficiently in an in vitro model of drug delivery to the human lung. J Appl Microbiol 105:380–388Google Scholar
- Palleroni NJ (1981) Introduction to the family Pseudomonadaceae. In: Starr MP, Stolp H, Truper HG, Balows A, Schlegel HG (eds) The prokaryotes. A handbook on habitats. Isolation and identification of bacteria. Springer-Verlag, Berlin, pp 655–665Google Scholar
- Schalk IJ (2007) Metal trafficking via siderophores in Gram-negative bacteria: specificities and characteristics of the pyoverdine pathway. J Inorg Biochem 102:1159–1169Google Scholar
- Smith EE et al. (2006) Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci USA 103:8487–8492Google Scholar