BioMetals

, Volume 22, Issue 2, pp 235–242

Antifungal activity and mode of action of silver nano-particles on Candida albicans

  • Keuk-Jun Kim
  • Woo Sang Sung
  • Bo Kyoung Suh
  • Seok-Ki Moon
  • Jong-Soo Choi
  • Jong Guk Kim
  • Dong Gun Lee
Article

DOI: 10.1007/s10534-008-9159-2

Cite this article as:
Kim, KJ., Sung, W.S., Suh, B.K. et al. Biometals (2009) 22: 235. doi:10.1007/s10534-008-9159-2

Abstract

In this study, the antifungal effects of silver nano-particles (nano-Ag) and their mode of action were investigated. Nano-Ag showed antifungal effects on fungi tested with low hemolytic effects against human erythrocytes. To elucidate the antifungal mode of action of nano-Ag, flow cytometry analysis, a glucose-release test, transmission electron microscopy (TEM) and the change in membrane dynamics using 1,6-diphenyl-1,3,5-hexatriene (DPH), as a plasma membrane probe, were performed with Candida albicans. The results suggest nano-Ag may exert an antifungal activity by disrupting the structure of the cell membrane and inhibiting the normal budding process due to the destruction of the membrane integrity. The present study indicates nano-Ag has considerable antifungal activity, deserving further investigation for clinical applications.

Keywords

Silver nano-particles Antifungal activity Candida albicans Membrane disruption 

Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Keuk-Jun Kim
    • 1
  • Woo Sang Sung
    • 1
  • Bo Kyoung Suh
    • 1
  • Seok-Ki Moon
    • 2
  • Jong-Soo Choi
    • 2
  • Jong Guk Kim
    • 1
  • Dong Gun Lee
    • 1
  1. 1.Department of Microbiology, College of Natural SciencesKyungpook National UniversityDaeguSouth Korea
  2. 2.Department of Dermatology, College of MedicineYeungnam UniversityDaeguSouth Korea

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