Advertisement

Biometals

, Volume 18, Issue 1, pp 7–13 | Cite as

Nickel Exposure and its Effects

  • Temir A. Demir
  • Burhanettin Işıklı
  • Selim M. Ürer
  • Asiye Berber
  • Tamer Akar
  • Mediha Canbek
  • Cemalettin Kalyoncu
Article

Abstract

The aim of the study was to determine the nickel concentrations of soil and plant specimens taken from a rural area exposed to cement factory emissions and also to determine the blood concentrations and sensitivity conditions observed in humans residing in this rural area. The study was carried out in Çukurhisar, a town in Eskişehir-Turkey, between May 2000 and March 2001. Beside the 108 soil (36 for control) and plant specimens, which were taken from 8 directions from the cement factory, blood samples of the individuals residing in this area were taken from 258 subjects (258 for control) following a physical examination, and patch tests were also applied. The nickel concentrations of the soil and plant specimens taken from different places in different directions of the factory were higher than in the control areas. The physical examination of subjects did not reveal results different from those of the control group except for the diagnosis of contact dermatitis. The analyses of venous blood samples showed that nickel concentrations were found to be within the reference values given for both groups, but higher in the subjects (p<0.001). According to the results of patch tests, sensitivity to nickel was found to be more frequent for the subject group than the control group (p<0.05). According to these results, clinical tools revealed no toxic effects for the subjects, except contact dermatitis. However, sensitivity to patch tests showed that this subject group has been affected compared to the control group and that this effect increased with age.

Keywords

cement dermatitis nickel plant soil 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams, RM 1993Disorders due to Drugs and Chemical agentsFitzpatrick, Thomas BEisen, Arthur ZKlaus Wolff, Freedberg, Irein MFrank Austen, K eds. Dermatology in General Medicine Clinical DermatologyMcGraw-Hill Inc.New York17671815Google Scholar
  2. Ayvaz, Z. 1992Çevre Kirliliği ve KontrolüPaper presented at the meeting of E.Ü.1.Uluslararası çre koruma sempozyumuIzmirGoogle Scholar
  3. Barrie LA. (1981) Atmospheric nickel in Canada. In: Effects of nickel in the Canadian environment, Ottawa, National Research Council of Canada pp. 55-76.Google Scholar
  4. Castiglioni, G, Corasva, A, Manzoni, S. 1992Results of routine patch testing of 834 patients in TurinContact Dermatitis27182185PubMedGoogle Scholar
  5. Gignac, LD, Beckett, PJ. 1986The effect of smelting operations on peatlands near Sudbury, Ontario, CanadaCan J Bot6411381147Google Scholar
  6. Grandjean, P. 1998NickelAlession, LBerlin, ABoris, M eds. Biological indicators for the assesment of human exposure to industrial chemicalsISPRA (Varese) Establishment Joint Research CentreCommission of the European Communities5680Google Scholar
  7. Grandjean P. (1992) Health significance of metals. In: Ed:Maxcy-Rosenau-Last, eds. Public health and preventive medicine. Prentice-Hall International Inc.Google Scholar
  8. Greig, JE, Carson, CF, Stuckey, MS, Riley, TV. 2000Prevalence of delayed hypersensitivity to the European standard series in a self-selected populationAustral J Dermatol418689Google Scholar
  9. Gündüz, T. 1993Kalitatif analiz labotaruvar kitabıBilge yayıncılıkAnkaraGoogle Scholar
  10. IARC1984Nickel in the human environment IARC scientific publications No 53International Agency for Research on cancerLyon, FranceGoogle Scholar
  11. Kanerva, L, Jolanki, R, Estlander, T, Alanko, K, Savela, A. 2000Incidence rates of occupational allergic contact dermatitis caused by metalsAm J Contact Dermat11155160CrossRefPubMedGoogle Scholar
  12. Lee, TY, Lam, TH. 1996Patch testing of 490 patients in Hong KongContact Dermatitis352326PubMedGoogle Scholar
  13. Linden, JV, Hopfer, SM, Grossling, HR, Sunderman, FW. 1985Blood nickel concentrations in patients with stainless-steel hip prostheses.Ann Clin Lab Sci15459464PubMedGoogle Scholar
  14. Mattila, L, Kilpelainen, M,  et al. 2001Prevalence of nickel allergy among Finnish university students in 1995Contact Dermatitis44218223CrossRefPubMedGoogle Scholar
  15. Painter PC, Cope JY, Smith JL. (1999) Reference information for the clinical laboratory. In: Burtis CA, Ashwood ER. Tietz textbook of Clinical Chemistry. W.B. Saunders companyGoogle Scholar
  16. Prokipcak, B, Ormrod, DP. 1986Visible injury and growth responses of tomato and soybean to combinations of nickel, copper and ozoneWater Air Soil Pollut27329340Google Scholar
  17. Que Hee, SS, Boyle, JR. 1988Simultaneous Multielemental Analyses of some environmental and biological samples by inductively coupled plasma atomic emission spectrometryAnalyt Chem6010331042Google Scholar
  18. Rycroft, RJG. 1998Occupational dermatosesChampion, RHBurton, JLBurns, DABreathnach, SM. eds. Textbook of Dermatology.Blackwell ScienceLondon821861Google Scholar
  19. Schubert, H, Berova, N, Czemielewski, A,  et al. 1987Epidemiology of nickel allergyContact Dermatitis16122128PubMedGoogle Scholar
  20. Shallari S, Schwartz C, Hasko A, Morel JL. (1998) Heavy metals in soils and plants of serpentine and industrial sites of Albania. Science Total Environment 19, 209(2-3): 133-142Google Scholar
  21. Whalberg, JE. 1977Routine patch testing with cadmium chlorideContact Dermatitis3293296Google Scholar
  22. WHO1991Nickel: Environmental health criteria No: 108World Health OrganizationGenevaGoogle Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Temir A. Demir
    • 1
  • Burhanettin Işıklı
    • 2
  • Selim M. Ürer
    • 3
  • Asiye Berber
    • 1
  • Tamer Akar
    • 1
  • Mediha Canbek
    • 4
  • Cemalettin Kalyoncu
    • 2
  1. 1.Art and Science Faculty Department of ChemistryOsmangazi UniversityEskisehirTurkey
  2. 2.Medical Faculty Department of Public HealthOsmangazi UniversityEskisehirTurkey
  3. 3.Medical Faculty Department ofDermatologyOsmangazi UniversityEskisehirTurkey
  4. 4.Art and Science Faculty Department of BiologyOsmangazi UniversityEskisehirTurkey

Personalised recommendations