Novel metabolic pathway for salicylate biodegradation via phenol in yeast Trichosporon moniliiforme
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A novel metabolic pathway was found in the yeast Trichosporon moniliiforme WU-0401 for salicylate degradation via phenol as the key intermediate. When 20 mM salicylate was used as the sole carbon source for the growth of strain WU-0401, phenol was detected as a distinct metabolite in the culture broth. Analysis of the products derived from salicylate or phenol through reactions with resting cells and a cell-free extract of strain WU-0401 indicated that salicylate is initially decarboxylated to phenol and then oxidized to catechol, followed by aromatic ring cleavage to form cis-cis muconate.
KeywordsBiodegradation Metabolic pathway Phenol Salicylate Trichosporon moniliiforme
High-performance liquid chromatography
Hetero-nuclear multiple-bond connectivity
Nuclear magnetic resonance
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