Biotechnology Letters

, Volume 41, Issue 1, pp 47–57 | Cite as

Fumaric acid: production and separation

  • Roxana-Andreea Ilica
  • Lenuţa KloetzerEmail author
  • Anca-Irina Galaction
  • Dan Caşcaval


Fumaric acid is a valuable compound used in foods, beverages, detergents, animal feed, pharmaceuticals and miscellaneous industrial products. It is produced on a large scale by the petrochemical route but the current tendency is towards implementing “green production” and environmental friendly technologies like biotechnological production of fumaric acid using low-cost raw materials. In this context, numerous studies focus on improving the fermentation process not only by using renewable raw material and genetically modified microorganisms, but also by developing and applying different downstream techniques for easy recovery of fumaric acid from the fermented broth. This review presents the main methods for production and separation of fumaric acid, highlighting the advantages and disadvantages of these and the potential economic impact in industry.


Fermentation Fumaric acid Rhizopus Separation 



This work was supported by the Grant PN-III-P4-ID-PCE-2016-0100 authorized by The National Council for Scientific Research - Executive Unit for Financing Higher Education, Research, Development and Innovation (CNCS-UEFISCDI).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Faculty of Chemical Engineering and Environmental Protection “Cristofor Simionescu”“Gheorghe Asachi” Technical University of IaşiIasiRomania
  2. 2.Faculty of Medical Bioengineering“Grigore T. Popa” University of Medicine and Pharmacy of IasiIasiRomania

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