Making metabolism accessible and meaningful: is the definition of a central metabolic dogma within reach?
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Intermediary metabolism, a dominant research area before the emergence of molecular biology, is attracting renewed interest for fundamental and applied reasons as documented here. Nonetheless, the field may appear to be a thicket precluding entry to all but the most determined. Here we present a metabolic overview that makes this important and fascinating area accessible to a broad range of the molecular biological and biotechnological communities that are being attracted to biological problems crying out for metabolic solutions. This is accomplished by identifying seven key concepts, a so-called metabolic central dogma, that provide a core understanding analogous to the “Central Dogma of Molecular Biology” which focused upon maintenance and flow of genetic information.
KeywordsAbnormal metabolism Agricultural applications Fermentation medical applications Metabolic central dogma Metabolic errors Metabolic regulation Omics
This work has been greatly influenced by my association with mentors (the late Phil Hartman and Saul Roseman, Dieter Söll) and colleagues (Barry Bochner, Zhixiong Xue, Tina Van Dyk and Dana Smulski) all of whom are greatly appreciated.
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