Biotechnology Letters

, Volume 35, Issue 4, pp 559–563 | Cite as

Improved β-carotene production by oxidative stress in Blakeslea trispora induced by liquid paraffin

  • Xianmei Hu
  • Xiaojing Ma
  • Pingwah Tang
  • Qipeng YuanEmail author
Original Research Paper


When 3 % (v/v) liquid paraffin was added to the medium, β-carotene production increased from 397 to 715 mg l−1 in mated cultures of Blakeslea trispora. Liquid paraffin also enhanced the oxygen concentration and induce high oxidative stress, as observed by the increase in activities of superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD). After 84 h of cultivation in the presence of liquid paraffin, the activities of SOD, CAT and POD in B. trispora increased 77, 52.5 and 76.6 %, respectively.


β-Carotene Catalase Liquid paraffin Peroxidase Superoxide dismutase 



The authors would like to acknowledge the financial support of the National Natural Science Foundation of China (Nos. 20976009 and 21176018).


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Xianmei Hu
    • 1
  • Xiaojing Ma
    • 1
  • Pingwah Tang
    • 1
  • Qipeng Yuan
    • 1
    Email author
  1. 1.State Key Laboratory of Chemical Resource EngineeringCollege of Life Science and Technology, Beijing University of Chemical TechnologyBeijingPeople’s Republic of China

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