Photocatalytic and antimicrobial properties of surgical implant coatings of titanium dioxide deposited though cathodic arc evaporation
- 494 Downloads
Nanostructured crystalline titanium dioxide coatings deposited by cathodic arc evaporated on titanium grade five medical implant substrates were demonstrated to exhibit UV-induced photocatalytic activity that can be utilized to provide bactericidal effects against Staphylococcus epidermidis. The photocatalytic activity of the coatings was confirmed via degradation of Rhodamine B under UV illumination. A 90 % reduction of viable bacteria was achieved in a clinically suitable time of only 2 min with a UV dose of 2.4 J delivered at 365 nm. These results are encouraging for the development of antimicrobial surfaces in orthopedics and dentistry in order to prevent or treat post-surgical infections.
Purpose of work
To assess the possibility of employing photocatalysis for elimination of S. epidermidis, known to cause medical device related infections, under short enough times to be clinically useful on an implant surface produced with a technique that is suitable for mass production.
KeywordsAntimicrobial activity Coating Infection prevention Photocatalysis Surgical implants Titanium dioxide
The Swedish Science Council, The Carl Trygger Foundation, The Göran Gustafsson Foundation, The Swedish Foundation for Strategic Research and Vinnova are acknowledged for financially supporting our research.
- Brohede U, Forsgren J, Mihranyan A, Engqvist H, Strømme M (2009b) Fast loading, slow release—a new strategy for incorporating antibiotics to hydroxyapatite. Key Eng Mater 396–398:523–526Google Scholar
- Brunski JB, Puleo DA, Nanci A (2000) Biomaterials and biomechanics of oral and maxillofacial implants: current status and future developments. Int J Oral Max Implant 15:15–46Google Scholar
- Costerton JW, Montanaro L, Arciola CR (2005) Biofilm in implant infections: its production and regulation. Int J Artif Organs 11:1062–1068Google Scholar
- Ewald A, Glueckermann SK, Thull R, Gbureck U (2006) Antimicrobial titanium/silver PVD coatings on titanium. Biomed Eng 5:22Google Scholar
- Gamage J, Zhang Z (2010) Applications of photocatalytic disinfection. Int J Photoenergy 2010, Article ID 764870Google Scholar
- Guinier A (1994) Diffraction by an imperfect crystals lattice in X-ray diffraction in crystals. Dover Publications Inc, New York, p 378Google Scholar
- Lavernia CJ, Drakeford MK, Tsao AK, Gittelsohn A, Krackow KA, Hungerford DS (1995) Revision and primary hip and knee arthroplasty—a cost analysis. Clin Orthop Relat Res 11:136–141Google Scholar
- Ratkowsky DA, Olley J, McMeekin TA, Ball A (1981) Relationship between temperature and growth rate of bacterial cultures. J Bacteriol 149:1–5Google Scholar
- Temple J, Santy J (2004) Pin site care for preventing infections associated with external bone fixators and pins. Cochrane DB Syst Rev 1:CD004551Google Scholar