Biotechnology Letters

, Volume 32, Issue 11, pp 1571–1585

Flocculation protein structure and cell–cell adhesion mechanism in Saccharomyces cerevisiae

Review

Abstract

Cell–cell adhesion occurs in a broad spectrum of biological processes, of which yeast flocculation is an area of interest for evolutionary scientists to brewers and winemakers. The flocculation mechanism is based on a lectin-carbohydrate interaction but is not yet fully understood, although the first model dates back to the 1950s. This review will update the current understanding of the complex mechanism behind yeast flocculation. Moreover, modern technologies to measure the forces involved in single carbohydrate-lectin interactions, are discussed. The Flo1 protein has been extensively described as the protein responsible for strong flocculation. Recently, more research has been directed to the detailed analysis of this flocculin. Due to the advances in the field of bioinformatics, more information about Flo1p could be obtained via structurally or functionally related proteins. Here, we review the current knowledge of the Flo1 protein, with a strong emphasis towards its structure.

Keywords

Cell–cell adhesion Flo1p Flocculation FLO genes Flo proteins Saccharomyces cerevisiae 

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Laboratory of Structural BiologyVrije Universiteit BrusselBrusselsBelgium

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