Biodegradation and biotransformation of organofluorine compounds
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The carbon–fluorine bond is one of the strongest in nature, and the increasing use of organofluorine compounds in agriculture, human and veterinary medicine, and industry has raised concerns about their fate in the environment. Microorganisms can degrade organofluorine compounds, either via specific enzymatic hydrolysis of the C–F bond, or through transformation by catabolic enzymes with broad substrate specificities. Here our current understanding of organofluorine catabolism in microorganisms is summarised.
KeywordsBioremediation Dehalogenase Fluoride Fluoroaromatic Organofluoro compounds
The author thanks Ben Clark for helpful discussions during the preparation of the manuscript.
- Barbosa JD, de Oliveira CMC, Tokarnia CH et al (2003) Comparison of the sensibility of cattle and buffaloes to poisoning by Palicourea marcgravii (Rubiaceae). Pesqui Vet Bras 23:167–172Google Scholar
- Carvalho MF, Ferreira MIM, Moreira IS et al (2006) Long-term performance and microbial dynamics of an up-flow fixed bed reactor established for the biodegradation of fluorobenzene. Appl Environ Microbiol 71:555–562Google Scholar
- Kawasaki H, Miyoshi K, Tonomura K (1981) Purification, crystallization and properties of haloacetate halidohydrolase from Pseudomonas species. Agric Biol Chem 45:543–544Google Scholar
- Peelen S, Rietjens I, Boersma MG et al (1995) Conversion of phenol derivatives to hydroxylated products by phenol hydroxylase from Trichosporon cutaneum—a comparison of regioselectivity and rate of conversion with calculated molecular orbital substrate characteristics. Eur J Biochem 227:284–291CrossRefPubMedGoogle Scholar
- Tu LQ, Wright PFA, Rix CJ et al (2006) Is fluoroacetate-specific defluorinase a glutathione S-transferase? Comp Biochem Physiol C 143:59–66Google Scholar