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Biotechnology Letters

, Volume 32, Issue 2, pp 209–214 | Cite as

Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock

  • Sang Sik Yun
  • Sung Phil Kim
  • Mi Young Kang
  • Seok Hyun NamEmail author
Original Research Paper

Abstract

The effect of curcumin on lipopolysaccharide/d-galactosamine (LPS/GalN)-induced acute shock model of liver injury was examined in mice. The simultaneous administration of LPS (5–20 μg kg−1, i.p.) and GalN (700 mg kg−1, i.p.) markedly increased the serum tumor necrosis factor-α (TNF-α), glutamic oxaloacetic transaminase/glutamic pyruvic transaminase (GOT/GPT), and massive hepatic necrosis and inflammation, leading to 100% lethality. Pre-administration of curcumin (100 mg kg−1, i.p.) 3 h before induction with LPS/GalN imparted a large extent of protection against acute elevation in serum TNF-α and serum GOT/GPT. Hepatic necrosis and lethality caused by LPS/GalN was also greatly reduced by curcumin treatment. The results demonstrated that curcumin could protect mice from LPS/GalN-induced hepatic injury and inflammation through blockading TNF-α production, eventually raising the survival rate of septic-shock-induced mice.

Keywords

Curcumin Endotoxemic shock Hepatic injury Mice Tumor necrosis factor-α 

Notes

Acknowledgements

This work received grant support from the Agenda Program (No. 200901OFT113068122), Rural Development Administration, Republic of Korea.

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Sang Sik Yun
    • 1
  • Sung Phil Kim
    • 2
  • Mi Young Kang
    • 3
  • Seok Hyun Nam
    • 1
    Email author
  1. 1.Department of Biological ScienceAjou UniversitySuwonRepublic of Korea
  2. 2.Department of Molecular Science and TechnologyAjou UniversitySuwonRepublic of Korea
  3. 3.Department of Food Science and NutritionKyungpook National UniversityDaeguRepublic of Korea

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