Biotechnology Letters

, Volume 31, Issue 12, pp 1825–1835

Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering

  • Ziyad S. Haidar
  • Reggie C. Hamdy
  • Maryam Tabrizian
Review

Abstract

Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.

Keywords

Biomaterials Bone morphogenetic proteins Bone regeneration Controlled-release Nanoparticles Synthetic polymers 

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Ziyad S. Haidar
    • 1
    • 2
    • 3
    • 4
  • Reggie C. Hamdy
    • 3
    • 4
  • Maryam Tabrizian
    • 1
    • 2
    • 3
  1. 1.Faculty of DentistryMcGill UniversityMontréalCanada
  2. 2.Department of Biomedical Engineering, Faculty of MedicineMcGill UniversityMontréalCanada
  3. 3.Center for Biorecognition and BiosensorsMcGill UniversityMontréalCanada
  4. 4.Shriners Hospital for Children and Division of OrthopaedicsMontreal Children’s Hospital, McGill UniversityMontréalCanada

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