Biotransformation of zerumbone by Caragana chamlagu
- 131 Downloads
Suspension cultured cells of Caragana chamlagu (Leguminosae) converted zerumbone (1) into zerumbone epoxide (2) as the intermediate, (2R,3R,7R)-2,3-epoxy-9-humulen-8-one (3) and (2R,3S,7R)-2,3-epoxy-9-humulen-8-one (4) as new sesquiterpenes in 11%, 36% and 21% yields, respectively.
KeywordsBiotransformation Caragana chamlagu Oxidation-asymmetric reduction Zerumbone
This work was partially supported by a special research Grant-in-Aid for the promotion and mutual aid corporation for private school of Japan to Nihon University.
- Flitsch S, Gideon G, Ashcroft D (2002) Oxygenation of C–H and C=C bonds. In: Drauz K, Waldman H (eds) Enzyme catalysis in organic synthesis, vol III, 2nd edn. Wiley-VHC Verlag GmbH, Weinheim, pp 1065–1108Google Scholar