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Biotechnology Letters

, Volume 30, Issue 11, pp 2025–2029 | Cite as

Biotransformation of zerumbone by Caragana chamlagu

  • Hiroshi SakamakiEmail author
  • Ken-ichi Itoh
  • Susumu Kitanaka
  • Seiji Sawada
  • C. Akira Horiuchi
Original Research Paper

Abstract

Suspension cultured cells of Caragana chamlagu (Leguminosae) converted zerumbone (1) into zerumbone epoxide (2) as the intermediate, (2R,3R,7R)-2,3-epoxy-9-humulen-8-one (3) and (2R,3S,7R)-2,3-epoxy-9-humulen-8-one (4) as new sesquiterpenes in 11%, 36% and 21% yields, respectively.

Keywords

Biotransformation Caragana chamlagu Oxidation-asymmetric reduction Zerumbone 

Notes

Acknowledgments

This work was partially supported by a special research Grant-in-Aid for the promotion and mutual aid corporation for private school of Japan to Nihon University.

References

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Hiroshi Sakamaki
    • 1
    Email author
  • Ken-ichi Itoh
    • 1
  • Susumu Kitanaka
    • 2
  • Seiji Sawada
    • 3
  • C. Akira Horiuchi
    • 4
  1. 1.College of Science and TechnologyNihon UniversityFunabashi-shiJapan
  2. 2.College of PharmacyNihon UniversityFunabashi-shiJapan
  3. 3.Kyoto University of EducationKyotoJapan
  4. 4.Department of ChemistryRikkyo (St. Paul’s) UniversityTokyoJapan

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