Biotechnology Letters

, Volume 30, Issue 3, pp 475–479 | Cite as

Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses

  • Jayanta Haldar
  • Jianzhu Chen
  • Terrence M. Tumpey
  • Larisa V. Gubareva
  • Alexander M. Klibanov
Original Research Paper

Abstract

Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs.

Keywords

Antiviral Polyethylenimine Quaternary amines Relenza Tamiflu 

Notes

Acknowledgements

This work was partly supported by the US Army through the Institute of Solider Nanotechnology under contact DAAD-19-02-D0002 with the Army Research Office and by NIH grant AI56267. We wish to thank Dr. Alexander Klimov (Influenza Division, CDC) for providing wild-type and oseltamivir-resistant strains of influenza A/Wuhan/359/95 (H3N2)-like virus.

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Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Jayanta Haldar
    • 1
  • Jianzhu Chen
    • 2
  • Terrence M. Tumpey
    • 3
  • Larisa V. Gubareva
    • 3
  • Alexander M. Klibanov
    • 1
  1. 1.Departments of Chemistry and Biological EngineeringMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.Center for Cancer Research and Department of BiologyMassachusetts Institute of TechnologyCambridgeUSA
  3. 3.Centers for Disease Control and PreventionAtlantaUSA

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