Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses
- 206 Downloads
Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs.
KeywordsAntiviral Polyethylenimine Quaternary amines Relenza Tamiflu
This work was partly supported by the US Army through the Institute of Solider Nanotechnology under contact DAAD-19-02-D0002 with the Army Research Office and by NIH grant AI56267. We wish to thank Dr. Alexander Klimov (Influenza Division, CDC) for providing wild-type and oseltamivir-resistant strains of influenza A/Wuhan/359/95 (H3N2)-like virus.
- Haldar J, Weight AK, Klibanov AM (2007) Preparation, application, and testing of permanently antibacterial and antiviral coatings. Nat Protoc 2 (in press)Google Scholar
- Wright PF, Webster RG (2001) Orthomyxoviruses, fields virology. Lippincott Williams & Wilkins, Philadelphia, pp 1533–1579Google Scholar