Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses
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Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs.
KeywordsAntiviral Polyethylenimine Quaternary amines Relenza Tamiflu
This work was partly supported by the US Army through the Institute of Solider Nanotechnology under contact DAAD-19-02-D0002 with the Army Research Office and by NIH grant AI56267. We wish to thank Dr. Alexander Klimov (Influenza Division, CDC) for providing wild-type and oseltamivir-resistant strains of influenza A/Wuhan/359/95 (H3N2)-like virus.
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