Biotechnology Letters

, Volume 29, Issue 3, pp 333–339 | Cite as

Biotechnologies in new high-throughput food allergy tests: why we need them

  • Neil K. Renault
  • Luciana Mirotti
  • Marcos J. C. Alcocer
Review

Abstract

The increase in prevalence of food allergies generates a need for more accurate and reliable quantitative allergy testing in order to help diagnosis. In this short review, we briefly outline the history of food allergy testing and extend our comments to current multiplex techniques. Particular emphasis is given to new developments in the protein microarray area, where the use of recent advances in biotechnology has the potential to produce high-throughput devices with improved clinical significance.

Keywords

Allergy testing Basophil Food allergy High-throughput Immunoglobulins Protein microarray 

References

  1. Aas K, Backman A, Belin L et al (1978) Standardization of allergen extracts with appropriate methods—combined use of skin prick testing and radio-allergosorbent tests. Allergy 33:130–137PubMedGoogle Scholar
  2. Alcocer MJC, Murtagh GJ, Wilson PB et al (2004) The major human structural IgE epitope of the Brazil nut allergen Ber e 1: A chimaeric and protein microarray approach. J Mol Biol 343:759–769PubMedCrossRefGoogle Scholar
  3. Arntz Y, Seelig JD, Lang HP et al (2003) Label-free protein assay based on a nanomechanical cantilever array. Nanotechnology 14:86–90CrossRefGoogle Scholar
  4. Bacarese-Hamilton TGJ, Ardizzoni A, Crisanti A (2005) Allergen microarrays. Method Mol Med 144:195–207Google Scholar
  5. Barry R, Soloviev M (2004) Quantitative protein profiling using antibody arrays. Proteomics 4:3717–3726PubMedCrossRefGoogle Scholar
  6. Belov L, de la Vega O, dos Remedios CG et al (2001) Immunophenotyping of leukemias using a cluster of differentiation antibody microarray. Cancer Res 61:4483–4489PubMedGoogle Scholar
  7. Bertone P, Snyder M (2005) Advances in functional protein microarray technology. Febs J 272:5400–5411PubMedCrossRefGoogle Scholar
  8. Blackley C (1959) Experimental researches on the causes and nature of Cartarrhus Aestivus (Hayfever or Hay-Asthma). Dawson’s of Pall MallGoogle Scholar
  9. Dyukova VI, Shilova NV, Galanina OE et al (2006) Design of carbohydrate multiarrays. Biochim Biophys Acta—General Subjects 1760:603–609CrossRefGoogle Scholar
  10. Fall BI, Eberlein-Konig B, Behrendt H et al (2003) Microarrays for the screening of allergen-specific IgE in human serum. Anal Chem 75:556–562PubMedCrossRefGoogle Scholar
  11. Geierstanger BH, Saviranta P, Brinker A (2006) Antibody microarrays using resonance light-scattering particles for detection. Methods Mol Biol 328:31–50PubMedGoogle Scholar
  12. Haab BB, Lizardi PM (2006) RCA-enhanced protein detection arrays. Methods Mol Biol 328:15–29PubMedGoogle Scholar
  13. Haab BB (2003) Methods and applications of antibody microarrays in cancer research. Proteomics 3:2116–2122PubMedCrossRefGoogle Scholar
  14. Harwanegg C, Hiller R (2004) Protein microarrays in diagnosing IgE-mediated diseases: spotting allergy at the molecular level. Exp Rev Mol Diagn 4:539–548CrossRefGoogle Scholar
  15. Harwanegg C, Hiller R (2005) Protein microarrays for the diagnosis of allergic diseases: state-of-the-art and future development. Clin Chem Lab Med 43:1321–1326PubMedCrossRefGoogle Scholar
  16. Harwanegg C, Laffer S, Hiller R et al (2003) Microarrayed recombinant allergens for diagnosis of allergy. Clin Exp Allergy 33:7–13PubMedCrossRefGoogle Scholar
  17. Hashmi G, Shariff T, Seul M et al (2005) A flexible array format for large-scale, rapid blood group DNA typing. Transfusion 45:680–688PubMedCrossRefGoogle Scholar
  18. Hiller R, Laffer S, Harwanegg C et al (2002) Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J 16:U262–U282Google Scholar
  19. Huang JX, Mehrens D, Wiese R et al (2001) High-throughput genomic and proteomic analysis using microarray technology. Clin Chem 47:1912–1916PubMedGoogle Scholar
  20. Ishizaka K, Ishizaka T (1967) Identification of gamma-E-antibodies as a carrier of reaginic activity. J Immunol 99:1187–1198Google Scholar
  21. Jahn-Schmid B, Harwanegg C, Hiller R et al (2003) Allergen microarray: comparison of microarray using recombinant allergens with conventional diagnostic methods to detect allergen-specific serum immunoglobulin E. Clin Exp Allergy 33:1443–1449PubMedCrossRefGoogle Scholar
  22. Kim TE, Park SW, Cho NY et al (2002) Quantitative measurement of serum allergen-specific IgE on protein chip. Exp Mol Med 34:152–158PubMedGoogle Scholar
  23. Kingsmore SF, Patel DD (2003) Multiplexed protein profiling on antibody-based microarrays by rolling circle amplification. Curr Opin Biotechnol 14:74–81PubMedCrossRefGoogle Scholar
  24. Kukar T, Eckenrode S, Gu YR et al (2002) Protein microarrays to detect protein–protein interactions using red and green fluorescent proteins. Anal Biochem 306:50–54PubMedCrossRefGoogle Scholar
  25. Kusnezow W, Hoheisel JD (2003) Solid supports for microarray immunoassays. J Mol Recogn 16:165–176CrossRefGoogle Scholar
  26. Lebrun SJ, Petchpud WN, Hui A et al (2005) Development of a sensitive, colorometric microarray assay for allergen-responsive human IgE. J Immunol Methods 300:24–31PubMedCrossRefGoogle Scholar
  27. Lee KB, Park SJ, Mirkin CA et al (2002) Protein nanoarrays generated by dip-pen nanolithography. Science 295:1702–1705PubMedCrossRefGoogle Scholar
  28. MacBeath G, Schreiber SL (2000) Printing proteins as microarrays for high-throughput function determination. Science 289:1760–1763PubMedGoogle Scholar
  29. Madsen C (2005) Prevalence of food allergy: an overview. Proc Nutr Soc 64:413–417PubMedCrossRefGoogle Scholar
  30. Merkel JS, Michaud GA, Salcius M et al (2005) Functional protein microarrays: just how functional are they? Curr Opin Biotechnol 16:447–452PubMedCrossRefGoogle Scholar
  31. Molloy RM, Mc Connell RI, Lamont JV et al (2005) Automation of biochip array technology for quality results. Clin Chem Lab Med 43:1303–1313PubMedCrossRefGoogle Scholar
  32. Moody MD, Van Arsdell SW, Murphy KP, Orencole SF, Burns C (2001) Array-based ELISAs for high-throughput analysis of human cytokines. Biotechniques 31:186–190, 192–194Google Scholar
  33. Nielsen UB, Cardone MH, Sinskey AJ et al (2003) Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci USA 100:9330–9335PubMedCrossRefGoogle Scholar
  34. Nielsen UB, Geierstanger BH (2004) Multiplexed sandwich assays in microarray format. J Immunol Methods 290:107–120PubMedCrossRefGoogle Scholar
  35. Pavlickova P, Schneider EM, Hug H (2004) Advances in recombinant antibody microarrays. Clin Chim Acta 343:17–35PubMedCrossRefGoogle Scholar
  36. Predki PF (2004) Functional protein microarrays: ripe for discovery. Curr Opin Chem Biol 8:8–13PubMedCrossRefGoogle Scholar
  37. Sampson HA (2004) Update on food allergy. J Allergy Clin Immunol 113:805–819PubMedCrossRefGoogle Scholar
  38. Sampson HA (2005) Food allergy—accurately identifying clinical reactivity. Allergy 60:19–24PubMedCrossRefGoogle Scholar
  39. Sasakura Y, Kanda K, Fukuzono S (2006) Microarray techniques for more rapid protein quantification: use of single spot multiplex analysis and a vibration reaction unit. Anal Chim Acta 564:53–58CrossRefGoogle Scholar
  40. Saviranta P, Okon R, Brinker A et al (2004) Evaluating sandwich immunoassays in microarray format in terms of the ambient analyte regime. Clin Chem 50:1907–1920PubMedCrossRefGoogle Scholar
  41. Schweitzer B, Roberts S (1998) Multiplexed protein profiling on microarrays by rolling-circle amplification. Nat Biotechnol 20:359–365CrossRefGoogle Scholar
  42. Schweitzer B, Roberts S, Grimwade B et al (2002) Multiplexed protein profiling on microarrays by rolling-circle amplification. Nat Biotechnol 20:359–365PubMedCrossRefGoogle Scholar
  43. Seltzer JM, Halpern GM, Tsay YG (1984) Correlation of allergy test-results obtained by IgE fast, rast, and prick-puncture methods. Ann Allergy 52:240–240Google Scholar
  44. Shreffler WG, Lencer DA, Bardina L et al (2005) IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2. J Allergy Clin Immunol 116:893–899PubMedCrossRefGoogle Scholar
  45. Steinhauer C, Ressine A, Marko-Varga G et al (2005) Biocompatibility of surfaces for antibody microarrays: design of macroporous silicon substrates. Anal Biochem 341:204–213PubMedCrossRefGoogle Scholar
  46. Uttamchandani M, Walsh DP, Yao SQ et al (2005) Small molecule microarrays: recent advances and applications. Curr Opin Chem Biol 9:4–13PubMedCrossRefGoogle Scholar
  47. Wang CC, Huang RP, Sommer M et al (2002) Array-based multiplexed screening and quantitation of human cytokines and chemokines. J Proteome Res 1:337–343PubMedCrossRefGoogle Scholar
  48. Wide L, Bennich H, Johansson SG (1967) Diagnosis of allergy by an in-vitro test for allergen antibodies. Lancet 2:1105–1107Google Scholar
  49. Wiese R, Belosludtsev Y, Powdrill T et al (2001) Simultaneous multianalyte ELISA performed on a microarray platform. Clin Chem 47:1451–1457PubMedGoogle Scholar
  50. Wodicka L, Dong H, Mittmann M et al (1997) Genome-wide expression monitoring in Saccharomyces cerevisiae. Nat Biotechnol 15:1359–1367PubMedCrossRefGoogle Scholar
  51. Woodbury RL, Varnum SM, Zangar RC (2002) Elevated HGF levels in sera from breast cancer patients detected using a protein microarray ELISA. J Proteome Res 1:233–277PubMedCrossRefGoogle Scholar
  52. Yguerabide J, Yguerabide EE (2001) Resonance light scattering particles as ultrasensitive labels for detection of analytes in a wide range of applications. J Cell Biochem Suppl 37:71–81PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Neil K. Renault
    • 1
  • Luciana Mirotti
    • 1
  • Marcos J. C. Alcocer
    • 1
  1. 1.School of Biosciences, Division of Nutritional SciencesUniversity of NottinghamLoughboroughUK

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