Biotechnology Letters

, Volume 28, Issue 20, pp 1633–1636 | Cite as

Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase

  • C. Chidananda
  • L. Jagan Mohan Rao
  • A. P. Sattur
Original Paper


Aldose reductase, the first key enzyme in the polyol pathway, is involved in complications of diabetes. Sclerotiorin, isolated and purified from the fermented broth of Penicillium frequentans, inhibited aldose reductase with an IC50 0.4 µM. The inhibitor also showed antibacterial activity against Bacillus spp.


Aldose reductase Diabetes Hyperglycemia Inhibitor Penicillium frequentans Sclerotiorin 


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The authors thank the Director, CFTRI, Mysore, for providing facilities and Department of Biotechnology, New Delhi, India, for awarding grant to conduct this research work. Chidananda C is thankful for Council of Scientific and Industrial Research, New Delhi, India, for the award of senior research fellowship.


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Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • C. Chidananda
    • 1
  • L. Jagan Mohan Rao
    • 1
  • A. P. Sattur
    • 1
  1. 1.Fermentation Technology and Bioengineering DepartmentCentral Food Technological Research InstituteMysoreIndia

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