Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase
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Aldose reductase, the first key enzyme in the polyol pathway, is involved in complications of diabetes. Sclerotiorin, isolated and purified from the fermented broth of Penicillium frequentans, inhibited aldose reductase with an IC50 0.4 µM. The inhibitor also showed antibacterial activity against Bacillus spp.
KeywordsAldose reductase Diabetes Hyperglycemia Inhibitor Penicillium frequentans Sclerotiorin
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The authors thank the Director, CFTRI, Mysore, for providing facilities and Department of Biotechnology, New Delhi, India, for awarding grant to conduct this research work. Chidananda C is thankful for Council of Scientific and Industrial Research, New Delhi, India, for the award of senior research fellowship.
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