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Biotechnology Letters

, Volume 28, Issue 10, pp 687–695 | Cite as

Tailored recombinant elastin-like polymers for advanced biomedical and nano(bio)technological applications

  • F. Javier Arias
  • Virginia Reboto
  • Susana Martín
  • Isabel López
  • J. Carlos Rodríguez-CabelloEmail author
Article

Abstract

The genetic engineering of protein-based polymers is a method that enables, in an easy way, the design of complex and highly functional macromolecules. As examples of this approach, different molecular designs are presented, with increasing degree of complexity, showing how the controlled increase in their complexity yields (multi)functional materials with more selected and sophisticated properties. The simplest designs show interesting properties already, but the adequate introduction of given chemical functions along the polymer chain provides an opportunity to expand the range of properties to enhanced smart behavior and self-assembly. Finally, examples are given where those molecular designs further incorporate selected bioactivities in order to develop materials for the most cutting edge applications in biomedicine and nano(bio)technology.

Keywords

Elastin-like polymers Genetic engineering Nanobiotechnology Protein-based polymers Smart polymers Tissue engineering 

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Notes

Acknowledgements

This work was supported by the “Junta de Castilla y León” (VA002/02), by the MCYT (MAT2000-1764-C02, MAT2001-1853-C02-01, MAT2003-01205 and MAT2004-03484-C02-01) and by the European Commission (Marie Curie Research Training Network BioPolySurf MRTN-CT-2004-005516).

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Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • F. Javier Arias
    • 1
  • Virginia Reboto
    • 1
  • Susana Martín
    • 1
  • Isabel López
    • 1
  • J. Carlos Rodríguez-Cabello
    • 1
    Email author
  1. 1.BIOFORGE research group, Dpto. Física de la Materia Condensada, E.T.S.I.I.Universidad de ValladolidValladolidSpain

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