Tailored recombinant elastin-like polymers for advanced biomedical and nano(bio)technological applications
- 301 Downloads
The genetic engineering of protein-based polymers is a method that enables, in an easy way, the design of complex and highly functional macromolecules. As examples of this approach, different molecular designs are presented, with increasing degree of complexity, showing how the controlled increase in their complexity yields (multi)functional materials with more selected and sophisticated properties. The simplest designs show interesting properties already, but the adequate introduction of given chemical functions along the polymer chain provides an opportunity to expand the range of properties to enhanced smart behavior and self-assembly. Finally, examples are given where those molecular designs further incorporate selected bioactivities in order to develop materials for the most cutting edge applications in biomedicine and nano(bio)technology.
KeywordsElastin-like polymers Genetic engineering Nanobiotechnology Protein-based polymers Smart polymers Tissue engineering
Unable to display preview. Download preview PDF.
This work was supported by the “Junta de Castilla y León” (VA002/02), by the MCYT (MAT2000-1764-C02, MAT2001-1853-C02-01, MAT2003-01205 and MAT2004-03484-C02-01) and by the European Commission (Marie Curie Research Training Network BioPolySurf MRTN-CT-2004-005516).
- Nicol A, Gowda DC, Parker TM, Urry DW (1994) Cell adhesive properties of bioelastic materials containing cell attachment sequences. In: Gebelein C, Carraher C (eds) Biotechnology and bioactive polymers. Plenum Press, New YorkGoogle Scholar
- Urry DW (1990) Preprogrammed drug delivery systems using chemical triggers for drug release by mechanochemical coupling. Polym Mater Sci Eng 63:329–336Google Scholar
- Urry DW (2005) What sustains life? Consilient mechanisms for protein-based machines and materials Springer-Verlag, LLC New YorkGoogle Scholar
- Urry DW, Nicol A, Gowda DC, Hoban LD, McKee A, Williams T, Olsen DB, Cox BA (1993) Medical Applications of bioelastic materials. In: Gebelein CG (ed) Biotechnological polymers: medical, pharmaceutical and industrial applications, Technomic Publishing Co. Inc., Atlanta, Georgia, pp 82–103Google Scholar