Rosin Nanoparticles as a Drug Delivery Carrier for the Controlled Release of Hydrocortisone
- 272 Downloads
Hydrocortisone (HC)-loaded rosin nanoparticles were prepared by a dispersion and dialysis method without addition of surfactant. They were spherical: 167–332 nm diam. The drug was loaded approximately 50% of initial feeding amount in all formulation. Release of hydrocortisone from the nanoparticles in vitro gradually decreased with increasing initial rosin content at pH 7.4. HC was also released very slowly at pH 1.2. Nanoparticles based on rosin thus are potentially useful as a drug delivery system.
Keywordsdrug release hydrocortisone nanoparticle rosin gum
Unable to display preview. Download preview PDF.
- Barabde UV, Fulzele SV, Satturwar PM, Dorle AK, Joshi SB, (2005) Film coating and biodegradation studies of new rosin derivative. React. Funct. Polym. In pressGoogle Scholar
- Dai, J, Nagai, T, Wang, X, Zhang, T, Meng, M, Zhang, Q 2004pH-sensitive nanoparticles for improving the oral bioavailability of cyclosporine AInt. J. Pharm.280229240Google Scholar
- Filipović-Grčić, J, Voinovich, D, Moneghini, M, Bećirević-Laćan, M, Magarotto, L, Jalsenjak, I 2000Chitosan microspheres with hydrocortisone and hydrocortisone-hydroxypropyl-β-cyclodextrin inclusion complexEur. J. Pharm. Sci.9373379Google Scholar
- Fulzele, SV, Satturwar, PM, Dorle, AK 2002Polymerized rosin: novel film forming polymer for drug deliveryInt. J. Pharm.24917584Google Scholar
- Fulzele, SV, Satturwar, PM, Dorle, AK 2003Study of the biodegradation and in vivo biocompatibility of novel biomaterialsEur. J. Pharm. Sci.205361Google Scholar
- Genta, I, Pavanetto, F, Conti, B, Giunchedi, P, Conte, U 1995Improvement of dexamethasone dissolution rate from spray-dried chitosan microspheresS.T.P. Pharma. Sci.5202207Google Scholar
- Jeong, YI, Cheon, JB, Kim, SH, Nah, JW, Lee, YM, Sung, YK, Akaite, T, Cho, CS 1998Clonazepam release from core-shell type nanoparticles in vitroJ. Control. Release51169178Google Scholar
- Jung, SW, Jeong, YI, Kim, SH 2003Characterization of hydrophobized pullulan with various hydrophobicitiesInt. J. Pharm.254109121Google Scholar
- Lee, CM, Lim, S, Kim, GY, Kim, D, Kim, DW, Lee, HC, Lee, KY 2004Rosin microparticles as drug carriers: Influence of various solvents on the formation of particles and sustained-release of indomethacinBiotechnol. Bioproc. Eng.9476481Google Scholar
- Mandaogade, PM, Satturwar, PM, Fulzele, SV, Gogte, BB, Dorle, AK 2002Rosin derivatives: novel film forming materials for controlled drug deliveryReactive & Functional Polymers50233242Google Scholar
- Wilhelm, M, Zhao, CL, Wang, Y, Xu, R, Winnik, MA, Mura, JL, Riess, G, Croucher, MD 1991Poly (styrene-ethylene oxide) block copolymer micelle formation in water: a fluorescence probe studyMacromolecules2410331040Google Scholar