Haplogroup Structure and Genetic Variation Analyses of 60 Mitochondrial DNA Markers in Southern Shaanxi Han Population

  • Yuan-Yuan Wei
  • Zhan-Ping Ren
  • Xiao-Ye Jin
  • Wei Cui
  • Chong Chen
  • Yu-Xin Guo
  • Hao-Tian Meng
  • Bo-Feng ZhuEmail author
Original Article


Mitochondrial DNA (mtDNA) has been widely employed as one tool for the studies of human migration and phylogenetic evolution owing to the characteristics of its lack of recombination and matrilineal inheritance. In this study, we analyze genetic distributions of 60 mtDNA markers in 126 unrelated individuals of Southern Shaanxi Han population and classify their haplogroups. Genetic distribution comparisons between Southern Shaanxi Han and other populations from different continents are conducted based on the same mtDNA markers. The majority of 60 mtDNA markers are polymorphic in Southern Shaanxi Han population. The most common haplogroups observed in Southern Shaanxi Han population are B5, followed by D5, A, D4e, and N9a1′3. Obtained matching probability for these 60 mtDNA markers indicates that the panel could be used as a valuable tool in forensic caseworks. Results of genetic distances (Fst) and multidimensional scaling analysis show that Southern Shaanxi Han population has relatively close genetic relationships with other Han populations in different regions. In conclusion, the panel comprising 60 mtDNA markers could be utilized for forensic applications in Southern Shaanxi Han population.


Southern Shaanxi Han mtDNA Haplogroup SNPs Forensic application 



The present work was supported by the National Natural Science Foundation of China (81525015) and Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (GDUPS, 2017).

Compliance with Ethical Standards

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yuan-Yuan Wei
    • 1
    • 2
  • Zhan-Ping Ren
    • 3
  • Xiao-Ye Jin
    • 4
  • Wei Cui
    • 4
  • Chong Chen
    • 4
  • Yu-Xin Guo
    • 4
  • Hao-Tian Meng
    • 1
    • 2
  • Bo-Feng Zhu
    • 1
    • 2
    • 5
    Email author
  1. 1.Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of StomatologyXi’an Jiaotong UniversityXi’anChina
  2. 2.Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of StomatologyXi’an Jiaotong UniversityXi’anChina
  3. 3.Department of Cranio-Maxillofacial Trauma Plastic SurgeryStomatology Hospital of Xi’an Jiaotong University College of MedicineXi’anChina
  4. 4.College of Forensic MedicineXi’an Jiaotong University Health Science CenterXi’anChina
  5. 5.Department of Forensic Genetics, School of Forensic MedicineSouthern Medical UniversityGuangzhouChina

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