Association of the IL6 Gene Polymorphism with Component Features of Metabolic Syndrome in Obese Subjects

  • Elham Barati
  • Hamideh Ghazizadeh
  • Fatemeh Sadabadi
  • Elham Kazemi
  • Gordon A. Ferns
  • Amir AvanEmail author
  • Majid Ghayour-MobarhanEmail author
Original Article


Metabolic syndrome (MetS) is a risk factor for type 2 diabetes mellitus and cardiovascular disease. Obesity is a component of the metabolic syndrome. Several genetic variants are reported to be associated with obesity and hypo adiponectinemia, including ars1800796 polymorphism of the interleukin-6 (IL-6) gene. Since obesity is associated with inflammatory factors, the aim of this study was to investigate the association between this polymorphism and MetS and its related features. Obese patients with body mass index (BMI) ≥ 30 (n = 182) were recruited into this study and divided into two groups; 110 patients with MetS, based on the International Diabetes Federation (IDF) criteria, and 72 subjects without MetS. The anthropometric and biochemical data for the groups were compared. Genotyping was carried out using RT-PCR. The association of the genetic polymorphism with MetS and its components were assessed using univariate and multivariate analyzes. There was an association between the presence of the rs1800796polymorphism of the IL-6 gene, with BMI (P = 0.031), high-density lipoprotein (HDL) (P = 0.010) and low-density lipoprotein (LDL) (P = 0.037), while this genetic variant did not show any significant association with the presence of MetS as defined by the IDF. We demonstrate an association between the rs1800796 genetic variant of the IL-6 gene with components of MetS including BMI, and HDL-cholesterol, but not the MetS itself. Therefore, supporting further studies are warranted to investigate this point in a larger population.


Metabolic syndrome BMI Gene polymorphism Obesity 



This study was supported by a grant from Mashhad University of Medical Sciences.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10528_2019_9913_MOESM1_ESM.docx (12 kb)
Supplementary material 1 (DOCX 12 KB)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Metabolic Syndrome Research CenterMashhad University of Medical SciencesMashhadIran
  2. 2.Fertility and Infertility Research CenterKermanshah University of Medical SciencesKermanshahIran
  3. 3.Brighton & Sussex Medical School, Division of Medical EducationFalmer, BrightonUK

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