Preliminary Report on the Association Between STAT3 Polymorphisms and Susceptibility to Acute Kidney Injury After Cardiopulmonary Bypass
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Cardiopulmonary bypass-associated acute kidney injury (CPB-AKI) is a well-recognized complication which is clearly linked to increased morbidity and mortality. Due to important role of inflammation in CPB-AKI pathogenesis, we explored the association between polymorphisms in STAT3, an inflammation-associated transcription factor, and the risk of CPB-AKI. In this study, STAT3 rs1053004 and rs744166 polymorphisms were analyzed in 129 patients undergoing coronary artery bypass grafting in Jorjani heart center, Bandar Abbas, Iran. The genotypes were determined using sequence-specific primers (PCR–SSP). Sixty-three patients met the criteria for AKI after cardiac surgery (AKI group). The remaining 66 patients did not develop AKI (non-AKI group). Rs1053004 GG genotype was significantly associated with a decreased risk (OR 0.4, 95% CI 0.17–0.9, P = 0.03) of CPB-AKI. Subgroup analyses revealed that GG genotype has also a protective effect in older patients (Age ≥ 60) (OR 0.19, 95% CI 0.04–0.8, P = 0.01). However, rs744166 did not show any difference between AKI and non-AKI groups. The result of our study for the first time provides evidence that rs1053004 polymorphism is significantly associated with a decreased risk of CPB-AKI in Iranian population, especially in older subjects.
KeywordsAcute kidney injury Cardiac surgery Cardiopulmonary bypass, polymorphism, Stat3
Cardiopulmonary bypass-associated acute kidney injury
Transducer and activator of transcription 3
- NKT cells
Natural killer T cells
Toll like receptor
Non-steroidal anti-inflammatory drugs
We extend our thanks to the research council of the Hormozgan University of Medical Sciences for their financial support.
NN developed the concept and prepared the manuscript; MR analyzed data, prepared manuscript, figures, and tables, and incorporated her suggestions; SA and FD performed experimentation; MK and HM performed examination on patients and handled sampling. All authors read and approved the final article.
Compliance with Ethical Standards
Conflict of interest
Authors declare that they had no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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