The Expression of Nuclear Transcription Factor Kappa B (NF-κB) in the Case of Critically Ill Polytrauma Patients with Sepsis and Its Interactions with microRNAs
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Critical polytrauma patients present a series of pathophysiological disturbances, biochemical and molecular dysfunction, which comprise to be the major cause of intensive care unit admission. In regard to molecular damage, there exists a series of factors, which all together contribute to the aggravation of the clinical status leading to increased mortality rate in these patients. One of the most important biochemical factors involved is the nuclear transcription factor B (NF-κB). Impaired NF-κB functioning is reflected on the clinical status of the patient through increased production of pro-inflammatory molecule, leading to multiple organ dysfunction syndrome. In addition to this, through microRNAs interactions, various pathophysiological as well as biochemical disturbances are produced, which altogether further reduce the patient’s survival rate. In this paper, we would like to present the modifications seen in the expression of NF-κB in critically polytraumatized patients with sepsis. In additions to this, we would like to discuss the correlation between the microRNAs and its further implications in clinical status of these patients.
KeywordsNuclear transcription factor kappa B (NF-κB) Sepsis microRNAs Polytrauma patients
- Chen J, Chen X, Lei Y et al (2011) Vascular protective potential of the total flavanol glycosides from Abacopteris penangiana via modulating nuclear transcription factor-κB signaling pathway and oxidative stress. J Ethnopharmacol 136:217–223. doi:10.1016/j.jep.2011.04.052 CrossRefPubMedGoogle Scholar
- Daniel Trancă S, Laura Petrişor C, Hagău N (2014) Biomarkers in polytrauma induced systemic inflammatory response syndrome and sepsis—a narrative review. Rom J Anaesth Intens Care 21:118–122Google Scholar