Three Novel SNPs in the Coding Region of the Bovine MC3R Gene and Their Associations with Growth Traits
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The involvement of melanocortin-3 receptor (MC3R) is well recognized in the regulation of feeding efficiency, body weight, and energy homeostasis. The objective of this study was to investigate the associations between MC3R gene polymorphisms and growth traits. Three novel SNPs (c.24C→T, c.220T→A, c.734G→C) and five haplotypes were identified in 234 Xiangxi cattle. The associations between MC3R gene polymorphisms and growth traits indicated that the individuals with TT and AT genotypes maintained higher body weight than those with the AA genotype at the c.220T→A locus (P < 0.05). The animals with GG and CG genotypes had higher heart girth and body weight than those with the CC genotype at c.734G→C (P < 0.05). The animals with H3H3 and H2H3 haplotype combinations had higher body weight than those with other haplotype combinations (P < 0.05). The results suggest that these SNPs in the MC3R gene might be useful genetic markers for marker-assisted selection and cattle breeding.
KeywordsCattle MC3R gene Polymorphism Growth traits Association analysis
We thank the reviewers and editor for helpful comments. This work was supported by the Open Scientific Research Project in the Provincial Platform of Life Sciences College, Hunan University of Arts and Science, China (SKYPT201207), the Natural Science Foundation of Hunan Province, China (11JJ4020), the Open Fund Project of Key Laboratory in Hunan Higher Education, China (11K045), the PhD Introduction Program of Hunan University of Arts and Science (BSQD1002), the Science-Technology Program Research Foundation of Hunan Province, China (2010NK3043), the Construct Program of the Key Discipline in Hunan Province.
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